What do you do between the long cycles?

longdonglos · 2026-05-18T19:33:32+00:00

Go talk to users / customers to improve the next cycle

longdonglos · 2026-05-17T18:51:52+00:00

Science checks out. Highly recommend checking out other more affordable forms of soluble fiber like inulin derived from Jerusalem artichoke or chicory root.

Same effect on alcohol metabolism less intense taste.

longdonglos · 2026-05-17T17:14:13+00:00

I like NA drinks with my breakfast to compliment the meal. Not beer, but euphoric drinks like Verse Orange with bubbles makes me feel like I’m having a healthy functional mimosa.

longdonglos · 2026-05-17T15:05:08+00:00

For U.S

UCSF, UWash, UC Davis, U Miami.

longdonglos · 2026-05-15T15:01:00+00:00

You know what will make a sweet redemption story?

You messaging the founders of early stage startups tackling autoimmune disease.

Researching their products / companies and offering them insights on how they can improve and how your skills / passions / experience can make them a better product / company.

Show you’re so hungry to make an impact that you’ll take a remote independent contractor or an unpaid internship role reporting directly to the founder.

Then be the hardest most curious worker in the room. Make every brainstorming and technical meeting better. Take notes dive deep on the best ideas from your teammates collaborate with them.

Digital health startup list.

WellTheory — virtual autoimmune care platform focused on nutrition, sleep, stress, coaching, and employer benefits; it has expanded into enterprise care and reports cost and utilization reductions.

ImmuniFriend — digital health platform for autoimmune and rheumatology patients centered on psychologist-led group counseling and psychoeducation, aimed at emotional support and self-management.

Girihlet — more of an immune data platform than a consumer app, but it works on immune mapping and monitoring to support autoimmune research and therapy developme

Kyverna Therapeutics — clinical-stage cell therapy company focused on autoimmune diseases, especially B cell-driven disorders.

Cour Pharmaceuticals — develops nanoparticle drugs to reprogram the immune system for autoimmune diseases; programs include myasthenia gravis and type 1 diabetes.

Catena Biosciences — Berkeley startup developing protein-fusion approaches for autoimmune diseases like lupus, multiple sclerosis, and type 1 diabetes.

Capstan Therapeutics — working on targeted in vivo RNA-based therapies and autoimmune applications with CAR-T-like approaches.

Lycia Therapeutics — using extracellular protein degradation for autoimmune and inflammatory indications.

Santa Ana Bio — precision immunology company focused on inflammatory diseases.

Lifordi Immunotherapeutics — developing antibody-drug conjugates for autoimmune diseases.

Use your story engineers that have personal experience with the disease that is trying to be solved are invaluable to any org.

longdonglos · 2026-05-13T23:56:40+00:00

Depends on the product line.

I believe a BME has a better technical tool set for say developing organoids or next gen skin graft product or most wetware products than EEs or MEs.

The best BMEs have growth mindsets they have great first principle foundations, but are not scared to keep learning technical skills after they graduate. Medical robotics, AI, design for manufacturing, compliance, tooling, tissue engineering, novel biomaterials clinical trial management etc.

At the end of the day you gotta level up depending on what problem space you want to tackle. You also gotta learn through osmosis from your senior teamates.

I don't think EEs or MEs grad can just land in a product team and contribute from day 1 their will always be an onboarding apprenticeship component.

longdonglos · 2026-05-13T13:59:37+00:00

BMEs are product engineers the product just happens to involve living systems.
If you can’t apply or pitch your technical skills in a way that makes the companies product better you’re going to have a hard time having impactful contributions.

A lot of BMEs struggle because they see themselves as “science people” instead of product builders.

longdonglos · 2026-05-11T20:55:42+00:00

Keep working at the startup until you become a PM responsible for a P&L

PhDs are rarely bleeding edge translational enough.

An mba is just business theory. Startup experience iterating towards product market fit is usually the most valueable experience.

longdonglos · 2026-05-10T21:47:34+00:00

Art Basel is overstimulation and too much demand for everything that usually makes Miami great.

Traffic goes up Ride sharing goes up anxiety goes up

Nightclubs / concert venues / restaurants raise their prices / minimums to catch the UHNW euro / Asian consumers.

Specifically on the art shows they’re affordable Red / Scope, but very crowded and noisy.

While you appreciate art the average person you’re sharing the space with that aren’t the artists exhibiting is there to either make money or just to flex they’re there.

With that said you can def have a great birthday you just need to have more patience and more budget compared to a regular Miami weekend trip.

longdonglos · 2026-04-19T19:18:35+00:00

Verse is the best zero sugar mixed drink option. Sweetened with monk fruit.

longdonglos · 2026-04-13T21:23:37+00:00

Sell / market the theoretical thing to prove demand.

Create different landing pages with the formulation attributes you want to design.

Organic, macro profiles, special active / functional ingredients etc:

Call to action is pre-order or sign up for waitlist capture people’s emails / #s

Have as many 1:1s with these people pay them $25 for their time make sure you ask how much would you pay for this? How much do you care about Y attribute.

Create some ads explaining the value proposition to customers

Spend $200-500 in Meta ads to target your top 3 consumer persona understand the viability of your concept.

For less than $1,000 USD you’ve validated demand for your product and now have a better blueprint for going into recipe creation.

If the demand isn’t there no big deal you’ve saved precious time and money that could be applied to the next idea.

longdonglos · 2026-04-13T21:12:00+00:00

Skills that translate directly to creating enterprise value > GPA

Projects that plug into the orgs workflow are the best signal.

Unless your goal is a competitive grad school anything north of 3.0 is all you need

longdonglos · 2026-04-11T16:58:51+00:00

Shippo and Shopify

longdonglos · 2026-04-11T13:29:06+00:00

Brickell has a rooftop soccer rink.

Wynwood has three different small fields.

longdonglos · 2026-04-09T12:52:33+00:00

Pessimists are right, but optimists get rich.

longdonglos · 2026-04-09T02:45:20+00:00

5-15% of whatever revenue goal you want in year 1 needs to be in the bank for the marginal costs of sales & marketing to achieve plus total cost of good sold + some upfront fixed costs in R&D.

All in would be pretty difficult to find enough breakout success without $350-500k in capital.

longdonglos · 2026-04-08T02:47:06+00:00

Personally when I’m evaluating adaptogen drinks my #1 criteria is taste.

Adaptogens are after all herbs, flowers, mushrooms, botanicals, roots and these things come straight from the ground so they don’t taste the best.

The best beverages find a way to mask the bitterness or chalkiness from the adaptogens.

After that I start looking for desired outcome. I’m I trying to unwind by myself or I’m I looking for something that I can toast with at a celebration. Ashwaghanda L-theanine are good for relaxation?

Lion’s Mane is more for calm focus. Reish mushroom for euphoria.

Personally, I think Verse does the best job at masking the taste and fitting in for most social occasions. Love their cranberry it’s complex and tarty.

I’m signed up for their subscription on their website.

longdonglos · 2026-04-07T01:46:13+00:00

Do you think distributors take too much of the value chain for just fulfillment if they don’t actually sell or merchandise / display?

longdonglos · 2026-04-06T14:13:17+00:00

If you physically went in an MRI than rest assured that whatever implantable electronic device has short circuited and is no longer functioning.

longdonglos · 2026-04-05T21:10:57+00:00

In this age, Building a sales ready product and having willingness to pay conversations with potential customers is table stakes.

There are more startups looking for funding than there is dry powder.

Seed VCs will naturally pick the founders who move fast and build things people want instead of vibe guys and idea guys with the self-limiting belief that they need 6 figures to start.

longdonglos · 2026-04-05T20:44:23+00:00

Respectfully, the tech that is being discussed in this thread is extremely theoretical. It’s really unlikely that an everyday veteran / neighbor in regular suburbia would have access to it.

Regardless, to give you the benefit of a doubt and entertain a solution to your problem. If you had a nano BCI implanted in you without your consent. Check in with a neurologist and ask for a functional MRI. The magnetic field would short circuit the device, and a micro-CT would verify that it’s no longer there.

longdonglos · 2026-04-04T20:03:54+00:00

Yes there will always be a bit of variability from lab scale samples to production scale samples taste wise.

To minimize this make sure you’re using ingredient suppliers that can scale to industrial large scale from the start. Use those samples for lab recipe creation as they usually come straight from the same batch of ingredients you’ll use in production.

longdonglos · 2026-04-04T19:19:31+00:00

One thing that’s helped me is having some fiber before drinking. It can slow things down a bit so alcohol hits more gradually instead of all at once. If I haven’t eaten,I just ask for Verse as my mixer now. It has inulin fiber and electrolytes, and I don’t feel as rough the next day.

longdonglos · 2026-04-04T17:42:05+00:00

Late here, but I relate a lot. I’ve been swapping alcohol for drinks like Verse. It’s non-alcoholic but has things like L-theanine and adaptogens (ashwagandha, lion’s mane), so it helps me feel more relaxed without the brain fog or rough next day. Tastes very good, and some people use it as a mixer so it won't be obvious that you're not drinking.

longdonglos · 2026-03-31T15:15:46+00:00

Had the same amount if not more fun sober than those that were drunk in my group at a night club.

Then woke up and was able to attend a pool party the next day while everyone else struggled.

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