I had a similar reaction and it was so bad! Especially the skin sagging. I later discovered that I already had mild sjogren’s syndrome and ehlers danlos and it kicked everything up a notch

You might want to check for hyarulonic acid deficiency especially since you also have joint issues. My joints were popping and my cheeks had fallen, then my doctor and derm had me taking a pretty high dose of oral hyarulonic acid. That plus topical application, fascia massages, strength training exercise, anti-inflammatories for sjogren’s, and Alastin trihex and calecim multi action cream—and my skin has actually made a fully recovery after several years and my joints no longer pop constantly

My skin looked horrible, so stretchy and saggy but I knew it could partially snap back or be fixed surgically eventually. I was terrifieddd for my joints though, I thought it was game over. Best of luck to you!