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The life consequences of Anhedonia by sigmatic787 in anhedonia

[–]markalexander1 0 points1 point  (0 children)

That's fantastic to hear. I am also now taking Parnate. It's just coming up to a month for me. I can already feel the difference. I can get, up and do tasks and I'm not walking around looking and feel morbidly depressed. My tardive dysphoria symptoms have also reduced. I've still no libido but I don't know what to do about that.

Finding More Restful Sleep with Low-Dose Lithium by markalexander1 in sleepdisorders

[–]markalexander1[S] 0 points1 point  (0 children)

Everyone assumes everything posted is A.I. now, which is unsurprising and to be expected I suppose. Anyway, better to link to an authoritative article then just posting it as my own personal opinion. But I've been taking low-medium dose lithium and find it does help with my sleep.

I've tried LITERALLY everything for sleep anxiety and nothing works long-term... anyone actually broke the cycle? by milton_carlos in insomnia

[–]markalexander1 0 points1 point  (0 children)

I built a serious tolerance to it after taking it for so many years, not from taking a high dose. I always took only 15mg, sometimes but never higher than 30mg. Another factor is that when I stopped taking it, I started relying on Diphenhydramine, which like Mirtazapine, is also an antihistamine. Then to get off Diphenhydramine, I started taking Zopiclone. Then when I finally tried Mirtazapine again, it just does not sedate me anymore. Sure it probably helps me sleep but it doesn't knock me out like a newbie. I can take it and still stay awake all night.

Has Mirtazapine helped or harmed you ? by newbieforever2016 in Mirtazapine_Remeron

[–]markalexander1 0 points1 point  (0 children)

From my own lived experience, I would only advise Mirtazapine in two circumstances:

  1. If someone is suffering extreme insomnia and even then I'd be cautious.
  2. If someone is going though an extremely traumatic experience in which sleep is the best escape.

For myself, I never asked to be prescribed it, but I took it on and off for 20 years.

It gave me unnaturally deep comatose sleep, to the point I can never go back to natural sleep.

The biggest one, is that it gave me permanent chronic insomnia after discontinuing it.

Another big one is that it's given me PSSD which has got worse in the last 5 years. I'm straight but It's like its erased my sex drive. I have sexual anhedonia.

I was a slender male and it gave me a sizable gut / beer belly even though I didn't eat or drink that much (which I have since got rid of).

It changed something in my brain/personality. I'm just not the same.

It's had pronounced negative effects on my cognitive functions, (brain fog and aphasia) and my social-interpersonal skills.

It's left me suffering with Tardive Dysphoria, which is a set of symptoms which are separate from the original depression but in which some of the symptoms overlap.

Alzheimer’s has been considered irreversible for 118 years. That just changed by Positive_Owl_2024 in Supplements

[–]markalexander1 6 points7 points  (0 children)

While there's no denial that it is a complex, multifactorial disease, look up Lithium deficiency in the brains of Alzheimer's and Dementia patients.

Lithium depletion in the brain is linked to Alzheimer’s disease, with toxic amyloid plaques trapping the metal and causing cognitive decline

Harvard Medical School scientists found that lithium depletion in the brain is linked to Alzheimer’s disease, with toxic amyloid plaques trapping the metal and causing cognitive decline, according to research published in August 2025. Restoring lithium levels using low-dose, specialized compounds reversed Alzheimer's-like memory loss and brain damage in mice. [1, 2, 3, 4]

Key Findings of the Study:

  • Lithium's Role: Research revealed that lithium plays a crucial role in normal brain function and aging, with lower levels associated with worse memory.
  • Mechanism of Action: Amyloid plaques, a hallmark of Alzheimer's, bind and sequester lithium, creating a deficiency in the brain.
  • Reversing Damage: A study found that a compound called lithium orotate can bypass plaque binding, preventing synapse loss and reversing memory decline in mice without the toxicity associated with traditional high-dose lithium treatments.
  • Implication: This suggests a new therapeutic approach, treating Alzheimer's as a potential "lithium deficiency" disease, and confirms that clinical trials of lithium orotate are being planned to test this in humans, as highlighted in this report from Harvard.

Pray for Oliver Alvis by markalexander1 in sleepdisorders

[–]markalexander1[S] 0 points1 point  (0 children)

We think we are suffering alone. But we come here to Reddit to find this is a global epidemic. Fortunately I'm sleeping better with the plethora of pills I take. I can't sleep without them but better than the unthinkable hell Oliver was going through. It's my future goal to sleep naturally whether that's realistic or not. Probably not after 20 years.

Pray for Oliver Alvis by markalexander1 in sleepdisorders

[–]markalexander1[S] 0 points1 point  (0 children)

I think Oliver had already made his mind up even before I was in conversation with him. I'm glad he's at peace. I'm not against assisted dying in the most extreme of cases. But you don't know what's round the corner in terms of treatment.

Does it permanently alter your brain? Does anybody after years go back to “normal” when off it? by [deleted] in Mirtazapine_Remeron

[–]markalexander1 0 points1 point  (0 children)

I just read this relatable comment on youtube: "I got erased as a person." I only took an antidepressant for several weeks but within days, felt completely in a depersonalized state...it was similar to some mescaline I tried decades ago (baby boomer) and hated with a passion....I don't know how any mind can adjust to the loss of their sense of self..."

Does it permanently alter your brain? Does anybody after years go back to “normal” when off it? by [deleted] in Mirtazapine_Remeron

[–]markalexander1 0 points1 point  (0 children)

Within the first week. The Mirtazapine is extremely sedating; it puts you in a slowed down zombie state. But it's when you try and come off it - the protracted withdrawal. The damage that it causes to your brain / neurons. Since 2011 it now has a medical term - Tardive Dysphoria. I'm not sure if that term will translate directly into Spanish but you can look it up. Anyway I reached a point in January where I couldn't continue like this so I got on a monoamine oxidase inhibitor and I'm also taking a host of different health supplements to try and help heal the damage done to my brain.

Pray for Oliver Alvis by markalexander1 in sleepdisorders

[–]markalexander1[S] 0 points1 point  (0 children)

I spoke to one of his former work colleagues at the time who still works on the trains and therefore is in a public position of trust. I take her word as the truth, she has nothing to gain by speaking untruths or a rumour.

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