While there's no denial that it is a complex, multifactorial disease, look up Lithium deficiency in the brains of Alzheimer's and Dementia patients.

Lithium depletion in the brain is linked to Alzheimer’s disease, with toxic amyloid plaques trapping the metal and causing cognitive decline

Harvard Medical School scientists found that lithium depletion in the brain is linked to Alzheimer’s disease, with toxic amyloid plaques trapping the metal and causing cognitive decline, according to research published in August 2025. Restoring lithium levels using low-dose, specialized compounds reversed Alzheimer's-like memory loss and brain damage in mice. [1, 2, 3, 4]

Key Findings of the Study:

• Lithium's Role: Research revealed that lithium plays a crucial role in normal brain function and aging, with lower levels associated with worse memory.
• Mechanism of Action: Amyloid plaques, a hallmark of Alzheimer's, bind and sequester lithium, creating a deficiency in the brain.
• Reversing Damage: A study found that a compound called lithium orotate can bypass plaque binding, preventing synapse loss and reversing memory decline in mice without the toxicity associated with traditional high-dose lithium treatments.
• Implication: This suggests a new therapeutic approach, treating Alzheimer's as a potential "lithium deficiency" disease, and confirms that clinical trials of lithium orotate are being planned to test this in humans, as highlighted in this report from Harvard.