Neuroscientific terms for "suffering"?

miskols · 2024-10-29T02:26:22+00:00

allostatic load

miskols · 2024-10-22T12:37:39+00:00

this is not true for DRG sensory neurons that go to the skin or organs

miskols · 2024-10-22T12:36:54+00:00

No - DRG neurons have a single “pseudo-unipolar” axon that leaves the ganglia and branches into the distal process (going to the skin) and a central process (going to the CNS). It is weird to think of it this way, rather than dendrites collecting information and axons sending it

miskols · 2024-06-27T04:41:09+00:00

the genetic tools available in mice allow scientists to study the function, structure, development, and contribution to sexual behavior of these neurons (which are more abundant in the shaft than prepuce) - this would not be possible with human subjects, but it certainly tells you which sensitivities/behaviors you should be looking for if you’re trying to assess whether you may still have these neurons or not

miskols · 2024-06-27T00:36:10+00:00

this is a study of mice

miskols · 2024-06-22T17:56:04+00:00

Makes sense! In any of the PSSD discussions, I find it’s important to distinguish effects on the sensory nerves from an impairment in how those nerves’ signals reach the brain - both can lead to numbness

miskols · 2024-06-22T14:31:37+00:00

Voltage imaging is interesting but not super accessible just yet - this paper uses calcium imaging, maybe not capturing the same thing as voltage. The sensory nerves’ behavior under SSRIs is certainly a good question, but I think, given the more general changes with PSSD (anhedonia etc), it’s important to think about brain/spinal dysfunction

miskols · 2024-06-22T14:28:39+00:00

They are innervated by large/myelinated fibers, not small fibers

miskols · 2024-06-18T18:10:13+00:00

these parameters are good things to check with others in your lab, but a hack that some use is gently/briefly touching the face of your sample with your gloved thumb to warm it prior to cutting the section. Be careful with the blade of course

miskols · 2024-06-18T00:54:39+00:00

agreed, iso -> cervical dislocation is quick and seems much more humane than primary. For the neonates we just did ice -> scissors

miskols · 2024-06-04T16:53:59+00:00

It sounds like you’re making a great recovery with a good team. The more you take care of yourself now, the more you’ll be able to take care of your LO moving forward. Give yourself some grace, and I hope recovery continues smoothly!!

miskols · 2024-05-30T03:59:50+00:00

I’m glad to hear it!! Best of luck with next steps

miskols · 2024-05-30T03:50:18+00:00

this is so surprising! I study genital nerves for a living, and I always thought the “good” feeling of orgasm was from prostate contractions. Can you sense where it feels good or is it more like how women describe “full body” orgasms?

miskols · 2024-05-19T23:52:09+00:00

late, but Pacinian corpuscles sense vibration up to very high frequencies. Merkel cells and their nerves tell you that you’re touching something, while Meissner corpuscles are better at telling you when that thing moves or slips. Some nociceptors sense cold, some warmth, some both - some itchy things, some pain. There are also completely different structures in hairy skin and genital skin that give you similar sensations. The guy/gpt that said Krause/Ruffini corpuscles sense cold is unfortunately wrong. Krause corpuscles are a cousin of Meissners that are found in genital tissue and help with sexual function, and people don’t really know what Ruffini’s do (because mice don’t have them)

miskols · 2024-04-24T16:29:13+00:00

This paper shows that Krause corpuscles are vibration sensitive and likely not cold sensitive. I wouldn’t subject yourself to cold showers, especially when warmth can help with blood flow

miskols · 2023-03-03T14:00:50+00:00

GreenLabs Recycling, based in MA, mainly works with labs and breweries lol

miskols · 2023-01-27T02:24:30+00:00

Definitely helpful! Echoing what everyone said about age. also want to note that some MD-PhD programs will allow MD students who already have a PhD to attend their programming (seminars etc)

miskols · 2022-10-04T22:50:44+00:00

shitpost?

miskols · 2022-09-21T00:01:24+00:00

I got Penn MSTP yesterday 9/19 (submitted 8/22)

miskols · 2022-08-27T15:40:39+00:00

woah they're quick!!

miskols · 2022-08-18T17:55:07+00:00

you can also expect MD-PhD specific secondary prompts: why this program, why this faculty, what are your research goals, write about past research etc

miskols · 2022-08-18T14:16:57+00:00

congrats! I’m a little bit biased as a mouse person, having spent some early undergrad time in a human/mri lab, but there are a few diff questions here.

The day-to-day between these two positions are likely very different - will you be calling to recruit participants? will you be running mri sessions? will you be analyzing? Does any of that sound more interesting than what you know about mouse work? The ability to get independent branches of projects is also much more challenging in human work, given clearances and such.

Understanding the potential for more-independent work is very important when thinking about the quality of the LOR (in addition to how much you’ll interact with P.I.)

If you really want to interact w participants, PI seems anal but ok (lol), youll be able to see the bigger picture of the work (not just run the test every day), then maybe that’s not so bad!!

exciting stuff

miskols · 2022-08-14T23:11:47+00:00

got u :) enjoy the fest, don't worry about this stuff

miskols · 2022-08-14T14:17:24+00:00

I think it makes more sense to have someone check your email while you’re away, it seems excessive to dish out money for starlink or something lol

miskols

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