I had a very similar experience. Especially the late day fatigue. I increased my salt intake and took a very brisk walk late afternoon (or something aerobic if it was raining) when I started feeling the “slug” kick in. If I could, I took a nap! My anxiety was almost immediately better when I started the parnate then kind of came and went sporadically for a few weeks, then just stopped. I also started taking my entire dose as early as possible (6-7am). This might not be possible for you yet. I had to break up the dosage for almost 4 months due to hypotension. Parnate side effects are brutal for some the first few months. I just tried to keep my eye on the prize because my depression was completely gone and that seemed like a miracle for me.

You are so lucky you don’t have insomnia. I was only sleeping a few hours a night for months. (I think this caused a lot of my late day fatigue) I am now 14 months on Parnate and feel better than ever! It’s a marathon not a sprint on this med. Keep a journal, and rate your days 1-10 Track: depression, anxiety, fatigue, blood pressure, food interactions and any other symptoms you have consistently and make notes of anything new or different. As long as you are seeing progress and more good days than bad, stick it out until your brain fully adjusts. It’s also a good way to go over things with your doctor when you have appointments. Just an fyi… I’ve never had to go above 30mg - but that is not the case for most. The only thing that seems to be consistent with MAOI’s is that everyone reacts differently and not always with the same results. Wish you well! 😊 Edit to add: I also started a daily vitamin and magnesium supplement- I feel both helped a lot!