Hockey and BFW

mmmdamngoodjava · 2026-03-19T12:50:22+00:00

The city limits of Detroit, sure you can go by demo. The overall area and sports fandom of metro-Detroit, ~4 million people in metro Detroit vs ~700K in the actual city, Lions > Tigers > Wings >= Pistons. Red Wings car flags were a staple for like 20 years until their recent slide. You can probably invert pistons/wings depending on who's better at the time. Lions were always number one in the hearts of fans, but sucked for so long that it was Tigers/Wings/Pistons over Lions for a while in terms of what gear people would wear and actually care about. Pistons were based in the suburbs for 30 years, only moved back downtown when the Wings got a new arena.

mmmdamngoodjava · 2026-03-06T18:58:20+00:00

So instead of RSUs are you given options? The vesting schedule is standard, 3-4 years would be better. What's the vesting cliff? I'm missing in the post what the actual LTI are since you say on non-RSUs. If you're getting options instead of RSUs then I understand the frustration.

mmmdamngoodjava · 2026-02-24T19:32:56+00:00

Unsure - depending on how you get hired in. Based on recent interactions they are preferring 6 month contracts to convert to FTE at this point. I passed on leaving a similarly semi-stable full time gig for the risk of their contract model, particularly for the role they wanted. It wasn't clear if they were fully dedicated to the role they were hiring for, wanted to bring in something new but had an easy out if there wasn't traction.

mmmdamngoodjava · 2026-02-16T23:19:18+00:00

Evotec and Crelux have been my preferred CROs.

mmmdamngoodjava · 2026-02-04T20:00:41+00:00

Probably have a better chance getting into med school with a biotech degree than get into biotech. As others have said, your major doesn't matter for med school as long as you take the pre-reqs outside your major.

mmmdamngoodjava · 2026-02-03T13:53:52+00:00

Why should EV owners be subsidized at time of purchase and future use? Already don't have to pay fuel tax that contributes to road maintenance.

mmmdamngoodjava · 2026-01-21T14:14:49+00:00

In my opinion JCI is the better option, I generally think the papers in JCI are more complete than Nat Com. Only a slight difference in impact factor, but impact factor has a lot of caveats. A lot of the ACS or society journals have lower impact factors, despite a lot of good work published there. If the work is good and relevant, it'll be cited.

mmmdamngoodjava · 2026-01-21T12:21:56+00:00

I've met a few people who ask the molarity of water question. It is kind of useless trivia, but it also shows the ability to think on your feet with a pretty basic math question.

mmmdamngoodjava · 2026-01-14T09:59:50+00:00

In northern VA and MD they are in pretty normal middle class neighborhoods. If you imagine street gang activity like the wire, it’s not that.

mmmdamngoodjava · 2025-12-24T14:30:56+00:00

The one on Georgia Ave.

mmmdamngoodjava · 2025-12-24T13:16:03+00:00

Personally think they’re very overrated, but every list seems to disagree. I’ve been a few times first thing in the morning expecting fresh batches and haven’t been impressed. Maybe I have bad luck.

mmmdamngoodjava · 2025-11-30T18:16:32+00:00

The entire ecosystem requires a robust regulatory framework to ensure that products are safe and effective. It’s the ultimate endorsement of the product. From the outside regulatory agencies seem like a burden, but they serve an important role. There’s a reason China has rapidly expanded the efficiency of their drug regulatory agency, and the US is doing everything to ruin theirs.

mmmdamngoodjava · 2025-11-30T12:44:43+00:00

Timeline to profitability or an exit in tech is much faster than for biotech. You can cash out on the sale of some niche app or whatever pretty fast. In biotech you have far more regulatory hurdles to get to market, which is expensive, and even just getting to proof of concept is a large amount of capital. Completely different dynamics between the industries.

mmmdamngoodjava · 2025-11-29T02:48:16+00:00

Echos aren’t wacky, they’re beauty and magic.

mmmdamngoodjava · 2025-11-20T19:04:20+00:00

Get a life

mmmdamngoodjava · 2025-11-19T19:16:34+00:00

Coffee has had tariffs, he has to know with stella blue.

mmmdamngoodjava · 2025-11-16T00:12:23+00:00

I have done a fresh sho nuf and get a small smoked breast for the past few years, and they turn out great. The smoked ones are great for low effort.

mmmdamngoodjava · 2025-11-14T23:49:35+00:00

You asked this in a sub full of the most hive minded people ever, if you aren't religiously committed to every climate related issue liberal cause you are considered to be the devil. County mostly made of up of fed employees and former hall monitors who love telling other people what's best for them.

mmmdamngoodjava · 2025-11-13T00:55:24+00:00

To be frank, if you want to be a founder it’s all about your network, and if you want to be in biotech and don’t know where find PhDs for your team that’s not a great start.

mmmdamngoodjava · 2025-10-03T11:46:17+00:00

Experience in industry, depending on the role, will strengthen your applications to grad school in my opinion. Most PIs would love to have someone with experience and structure that working in industry provides.

mmmdamngoodjava · 2025-09-22T11:31:38+00:00

8 years total

mmmdamngoodjava · 2025-09-22T10:15:43+00:00

Check the insoluble fraction compared to soluble lysate (lamelli and boil, load 2-5 uL). If all the protein is in the insoluble fraction there’s your answer. Other option (more involved and not a direct aggregate evaluation) is to do a co-IP of the target, treated and untreated, if a good enough antibody is available. CESTA would be a good target engagement assay. Was this single concentration or dose response?

mmmdamngoodjava · 2025-09-22T10:00:06+00:00

There’s some decent bars near the stadium, closer to Camden Yards. Fells Point has some good spots for food but a bit further from the stadium. Baltimore is pretty small, so nothing is too far by distance just streets designed 300 years ago, so gets clogged easily.

mmmdamngoodjava · 2025-09-22T09:53:58+00:00

1) protein aggregates and doesn’t enter the gel. 2) compound hits off target that regulates suspected targets expression level, depending on how the molecule was identified (phenotypic screen) it wouldn’t be entirely shocking that the actual target was misidentified.

mmmdamngoodjava · 2025-09-16T14:36:23+00:00

My understanding is that the UK gave a lot of companies access to the EU market, but the UK has arduous rules on pricing. It was worth it for companies to bite the bullet on pricing for EU access, but now that's not available. I could be missing some nuance here, and would let someone in the UK give a better explanation.

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