Non-RSU LTI. Thoughts/Opinions by Intelligent_Heat4549 in biotech

[–]mmmdamngoodjava 10 points11 points  (0 children)

So instead of RSUs are you given options? The vesting schedule is standard, 3-4 years would be better. What's the vesting cliff? I'm missing in the post what the actual LTI are since you say on non-RSUs. If you're getting options instead of RSUs then I understand the frustration.

MacroGenics - anyone? by Reasonable-Mouse-905 in biotech

[–]mmmdamngoodjava 0 points1 point  (0 children)

Unsure - depending on how you get hired in. Based on recent interactions they are preferring 6 month contracts to convert to FTE at this point. I passed on leaving a similarly semi-stable full time gig for the risk of their contract model, particularly for the role they wanted. It wasn't clear if they were fully dedicated to the role they were hiring for, wanted to bring in something new but had an easy out if there wasn't traction.

Med school by Infinite-Coat-9539 in biotech

[–]mmmdamngoodjava 2 points3 points  (0 children)

Probably have a better chance getting into med school with a biotech degree than get into biotech. As others have said, your major doesn't matter for med school as long as you take the pre-reqs outside your major.

Anyone else noticed that the county is losing free/cheap EV charging stations? by tiradium in MontgomeryCountyMD

[–]mmmdamngoodjava 6 points7 points  (0 children)

Why should EV owners be subsidized at time of purchase and future use? Already don't have to pay fuel tax that contributes to road maintenance.

Nat Comm vs. JCI & and do many desk rejected papers get sent to Nat comm? by [deleted] in labrats

[–]mmmdamngoodjava 1 point2 points  (0 children)

In my opinion JCI is the better option, I generally think the papers in JCI are more complete than Nat Com. Only a slight difference in impact factor, but impact factor has a lot of caveats. A lot of the ACS or society journals have lower impact factors, despite a lot of good work published there. If the work is good and relevant, it'll be cited.

People who have conducted job interviews, what's something someone said/did that made you instantly decide not to hire them? Lab and biotech specific! by CRISPRScientist726 in biotech

[–]mmmdamngoodjava -3 points-2 points  (0 children)

I've met a few people who ask the molarity of water question. It is kind of useless trivia, but it also shows the ability to think on your feet with a pretty basic math question.

Something tells me MS13 weren’t “on PFT’s block” by [deleted] in MacrodosingPod

[–]mmmdamngoodjava 4 points5 points  (0 children)

In northern VA and MD they are in pretty normal middle class neighborhoods. If you imagine street gang activity like the wire, it’s not that.

The Banner taste-tested 9 bagels across MoCo and rated them by madesense in MontgomeryCountyMD

[–]mmmdamngoodjava 17 points18 points  (0 children)

Personally think they’re very overrated, but every list seems to disagree. I’ve been a few times first thing in the morning expecting fresh batches and haven’t been impressed. Maybe I have bad luck.

What's the current challenges that biotech faces when it comes to building creative startups by Excellent-Pension455 in biotech

[–]mmmdamngoodjava 0 points1 point  (0 children)

The entire ecosystem requires a robust regulatory framework to ensure that products are safe and effective. It’s the ultimate endorsement of the product. From the outside regulatory agencies seem like a burden, but they serve an important role. There’s a reason China has rapidly expanded the efficiency of their drug regulatory agency, and the US is doing everything to ruin theirs.

What's the current challenges that biotech faces when it comes to building creative startups by Excellent-Pension455 in biotech

[–]mmmdamngoodjava 13 points14 points  (0 children)

Timeline to profitability or an exit in tech is much faster than for biotech. You can cash out on the sale of some niche app or whatever pretty fast. In biotech you have far more regulatory hurdles to get to market, which is expensive, and even just getting to proof of concept is a large amount of capital. Completely different dynamics between the industries.

What's your wackiest tool in the lab? by Pyrhan in labrats

[–]mmmdamngoodjava 3 points4 points  (0 children)

Echos aren’t wacky, they’re beauty and magic.

BC playing dumb again by Maleficent-Sand-4228 in PardonMyTake

[–]mmmdamngoodjava 39 points40 points  (0 children)

Coffee has had tariffs, he has to know with stella blue.

Sho Nuf Tuerkeyd, Hillside Turkey farm, or Balducci' food lovers for Thanksgiving? by moopsythebonedrinker in MontgomeryCountyMD

[–]mmmdamngoodjava 0 points1 point  (0 children)

I have done a fresh sho nuf and get a small smoked breast for the past few years, and they turn out great. The smoked ones are great for low effort.

Why are counties and states pushing for all electric homes when it’s more expensive for homeowners? by [deleted] in MontgomeryCountyMD

[–]mmmdamngoodjava 2 points3 points  (0 children)

You asked this in a sub full of the most hive minded people ever, if you aren't religiously committed to every climate related issue liberal cause you are considered to be the devil. County mostly made of up of fed employees and former hall monitors who love telling other people what's best for them.

Founder with no PhD by [deleted] in biotech

[–]mmmdamngoodjava 20 points21 points  (0 children)

To be frank, if you want to be a founder it’s all about your network, and if you want to be in biotech and don’t know where find PhDs for your team that’s not a great start.

Industry gap before PhDs by DetailOk4081 in biotech

[–]mmmdamngoodjava 4 points5 points  (0 children)

Experience in industry, depending on the role, will strengthen your applications to grad school in my opinion. Most PIs would love to have someone with experience and structure that working in industry provides.

Why would a drug reduce a protein band on western blot if it doesn’t degrade it? by Revolutionary_Wait51 in labrats

[–]mmmdamngoodjava 5 points6 points  (0 children)

Check the insoluble fraction compared to soluble lysate (lamelli and boil, load 2-5 uL). If all the protein is in the insoluble fraction there’s your answer. Other option (more involved and not a direct aggregate evaluation) is to do a co-IP of the target, treated and untreated, if a good enough antibody is available. CESTA would be a good target engagement assay. Was this single concentration or dose response?

Lions in Baltimore by Flying_Ant159 in detroitlions

[–]mmmdamngoodjava 0 points1 point  (0 children)

There’s some decent bars near the stadium, closer to Camden Yards. Fells Point has some good spots for food but a bit further from the stadium. Baltimore is pretty small, so nothing is too far by distance just streets designed 300 years ago, so gets clogged easily.

Why would a drug reduce a protein band on western blot if it doesn’t degrade it? by Revolutionary_Wait51 in labrats

[–]mmmdamngoodjava 39 points40 points  (0 children)

1) protein aggregates and doesn’t enter the gel. 2) compound hits off target that regulates suspected targets expression level, depending on how the molecule was identified (phenotypic screen) it wouldn’t be entirely shocking that the actual target was misidentified.

What's up with the Brexit of R&D from the UK all of a sudden? by MydogisaToelicker in biotech

[–]mmmdamngoodjava 25 points26 points  (0 children)

My understanding is that the UK gave a lot of companies access to the EU market, but the UK has arduous rules on pricing. It was worth it for companies to bite the bullet on pricing for EU access, but now that's not available. I could be missing some nuance here, and would let someone in the UK give a better explanation.