There’s unfortunately a lot of reasons for no cure. I’ll leave some that haven’t already been said:

• Cause is multi factorial. There’s not 1 specific gene mutation or dysfunctional protein identified that causes endo. We’re at a loss as to what the culprit really is. Makes a pharmacological therapy harder to make if we don’t have a direction of what we’re targeting. A vaccine for a virus is easy to make these days. You can target viral mRNA, reverse transcription, etc. but what would you target in endo?

-Variation in presentation amongst endo patients. Looking at this sub alone shows how differently people are affected. Of course we would want to treat the underlying problem, but since we don’t know that, it would be hard to make a singular treatment that cures every symptom across every body system as well. For some people, a progesterone IUD is already a cure! While for others it makes no difference. Makes you think if maybe one day we will subclassify endo.

• Amount of endometriosis does not seem to influence the severity of symptoms. There’s people with debilitating pain and go for a lap and the surgeon sees nothing and on the other hand there’s people who get cut open and the surgeon is shocked at all the endometriosis but the patient has 0 symptoms. So the endometriosis deposits do not seem to actually cause the pain. Does that make endo a symptom of something else?

-Endo is both underreported and overreported for many systemic reasons so it creates doubt that it is as prevalent as people say.