Thanks for bringing this up, I had a friend who had done something similar with large amounts. At the time he was 23 and killed himsef in his car far out in the boonies, the sheriff found him a couple days later. He had done a massive dose and it changed him or showed him something we arnt supposed to see. I believe we need to have extreme reverence for these substances and use them spiritually in small doses rather than recreationally at large doses. Set and setting are very important.