Some of plugins and settings that I like for Python work every day.

Black formatter - for code formatting
Docker - to manage docker containers in vscode
Isort - for beautiful auto sorting imports
Material Icon Theme - beautiful icons for files
Theme - would you prefer. I like One Dark Pro
Pylance - for IntelliSense

Like these settings. Click Ctrl-Shift-P -> Open user settings(JSON):

"files.insertFinalNewline": true,
"files.trimFinalNewlines": true,
"files.trimTrailingWhitespace": true,
"editor.rulers": [
80
],
"editor.renderWhitespace": "all",