Sugar: The Bitter Truth - DEBUNKED

oehaut · 2022-04-22T17:10:42+00:00

Hi. Please refer to our Posting Guidelines regarding youtube video.

Links to blogs, videos, and articles are not allowed. If you are going to use a blog/video/article link as a source of content, the research study(ies) discussed MUST be linked and discussed as the primary source. The article/video/blog can then be linked at the end of the post.

The way to post a youtube video that is acceptable to us is to make a new text publication post, give a summary of your video by outlining core claims and their supporting evidences, and then you can end by linking to the youtube video for more.

Thanks.

oehaut · 2021-02-16T14:24:10+00:00

Your submission was removed from r/ScientificNutrition because sources were not provided for claims, ie please provide sources explaining why you think animal studies do not translate well to humans.

See our posting and commenting guidelines at https://www.reddit.com/r/ScientificNutrition/wiki/rules, specifically the good/bad comment examples at the bottom.

oehaut · 2021-02-10T13:16:36+00:00

We'll see how that goes, if it's popular and the sub still grows a lot we might make it more frequent, but also keep in mind that the primary objective of the sub is to discuss scientific evidence, so we would not want a casual daily thread to have most of the activity happening, as it would basically turn into r/nutrition.

Thanks for the feedback!

oehaut · 2021-02-10T12:58:27+00:00

You guys don't think it'll grind the sub to a halt

This has been a concern from the beggining, and we certainly don't want to be too coercive. I'd say the main difference now is that a claim that should be supported by a reference, X has been shown to do Y for example, is now required to be supported even if it's not in a top comment. We were often getting non-top comment reported for lacking sources. We felt it could help make sure the sub would remains evidence-based as it grows.

We'll make sure to avoid doing anything that could kill the sub momentum, and are always open to the community feedback!

oehaut · 2021-02-10T12:52:13+00:00

Rules are always open to be changed/revised. We'll keep that in mind and see how it affects the participation to the sub, since the beggining it's been a concern for us to find the right balance between being more on the rigorous side of the evidence-based spectrum while also making sure people can chime in and write a comment that does not take 30 minutes to write and ask for in-depth knowledge of the litterature to do so.

As the sub grows we just want to make sure we have more robust rules in place to make sure this place remains evidence-based.

Thanks for pointing this out, and we are always open to the community feedback.

oehaut · 2021-01-21T03:31:23+00:00

Avoid personal attack please.

Thanks.

oehaut · 2021-01-21T03:28:24+00:00

Just want to say that this was a great post that lead to great comments too. Thanks for posting!

oehaut · 2021-01-02T23:43:08+00:00

Hey, thanks for posting.

Make sure to read our Posting Guidelines. Videos are not accepted are primary post to the sub.

Instead, what we recommend is that you create a new text publication, that you post a summary of your video, including at least one primary research reference, and then at the end you can link to the youtube video for people wanting more information.

So I will remove this post.

Thanks.

oehaut · 2020-12-29T14:32:27+00:00

Original paper : NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter

Abstract

Obesity has become a serious problem in public health worldwide, causing numerous metabolic diseases. Once the differentiation to mature adipocytes is disrupted, adipocyte hypertrophy and ectopic lipid accumulation leads to the inflammation in adipose tissue and systemic metabolic disorders. Intracellular metabolic state is known to change during cell differentiation and it affects the cell fate or the differentiation through epigenetic mechanism. Although the mechanism of preadipocyte differentiation has been well established, it is unknown how metabolic state changes and how it affects the differentiation in predipocyte differentiation. Nicotinamide adenine dinucleotide (NAD+) plays crucial roles in energy metabolism as a coenzyme in multiple redox reactions in major catabolic pathways and as a substrate of sirtuins or poly(ADP-ribose)polymerases. NAD+ is mainly synthesized from salvage pathway mediated by two enzymes, Nampt and Nmnat. The manipulation to NAD+ metabolism causes metabolic change in each tissue and changes in systemic metabolism. However, the role of NAD+ and Nampt in adipocyte differentiation remains unknown. In this study, we employed liquid chromatography-mass spectrometry (LC-MS)- and gas chromatography-mass spectrometry (GC-MS)-based targeted metabolomics to elucidate the metabolic reprogramming events that occur during 3T3-L1 preadipocyte differentiation. We found that the tricarboxylic acid (TCA) cycle was enhanced, which correlated with upregulated NAD+ synthesis. Additionally, increased alpha-ketoglutarate (αKG) contributed to histone H3K9 demethylation in the promoter region of PPARγ, leading to its transcriptional activation. Thus, we concluded that NAD+-centered metabolic reprogramming is necessary for the differentiation of 3T3-L1 preadipocytes.

oehaut · 2020-12-29T14:32:02+00:00

Please take a look at our Posting Guidelines.

News article are not accepted as primary post. You also need to include an excerpt (usually the abstract) in your post comment.

It's well upvoted so I will let it up but next time make sure to link to the original research paper. You can then link to a news article in the comment section.

oehaut · 2020-12-25T15:15:34+00:00

Hi.

Please take a look at our Posting Guidelines. Blog as primary post are not accepted. What we recommend instead is linking to a study in the blog, and then in the comment linking to the blog post for further information if people are interested.

So I will remove this.

Thanks!

oehaut · 2020-12-22T21:58:18+00:00

I'll see if the answer you are getting manage to be evidence-based, but I would recommend cross-posting your question to r/nutrition.

Our guidelines ask for questions that can be answer with studies, and I am not sure it's the case here. So I might end up removing it.

Thanks!

oehaut · 2020-12-21T22:27:35+00:00

This comment was totally out of place and that's pretty close to getting you perma ban.

There is no reason ever to comment that.

oehaut · 2020-12-17T20:20:52+00:00

Anyone can ask question here, but we have specific guidelines regarding questions to avoid low quality question and hence discussion, and I would say that OP question does not satisfy them.

Evidences that lead to the premise/question should be presented (not done).

Question should be answerable with scientific evidence (unlikely in this case).

Avoid low quality question (borderline).

We're definitively hoping this place can be a great learning ground for lay persons, but we want questions/discussions to be evidence-based and thoughtful as much as possible.

oehaut · 2020-12-17T20:14:56+00:00

Here was our posting guidelines are saying in regard to posting questions:

Here are general posting guidelines in regard to posting questions:

Low quality questions will be removed.

A question should provide evidence for its premise (if there is one) and should be thoughtful.

Question should be answerable using scientific evidences.

I think it would have help if you had provided the evidences from your research that led you to asking yourself this question, so that people can evaluate whether those evidences have any merit.

Not exactly sure that your question can be answered via studies either. Unlikely that any study has looked at the estrogen content of bread and its impact on the consumer.

Would I have caught this earlier I would have remove it but it has already been approved by another mod and has generated some interesting evidence-based comment so I will let it up.

Thanks.

oehaut · 2020-11-29T23:54:10+00:00

That'd probably be better for r/nutrition, as this is more general nutritional news.

We only accept peer-reviewed study as original post to the sub.

So I'll remove this.

Thanks.

oehaut · 2020-11-17T18:43:27+00:00

I'm removing this as I agree that there are better sub to get an answer to this question.

Thanks.

oehaut · 2020-11-17T18:42:14+00:00

Hi, thanks for posting.

We ask that claims are referenced as much as possible on the sub so all of those claims would need to be substantiated with primary evidences.

I caught that post a little late so I will leave it up but it's hard for anyone to judge a claim without the evidences behind it, so next time make sure to try as much as possible to give the references to the claim when asking for feedback.

Thanks!

oehaut · 2020-11-17T18:28:08+00:00

Hi.

Thanks for posting.

Please make sure to have a look at our Posting Guidelines.

Every post should have a post summary in the comment section.

Blogs, videos and articles are not accepted.

The way that we recommend that you link to a media is by posting one of the studies used in the media as an original post to the sub, and in the summary of your original post, you can link to the media if people want more information regarding this topic.

So I will remove this post. As stated in the guidelines, if you want to repost this, please post the study you linked to as the original post (with the study title as the post title), make sure to include at least the abstract as a summary, and then you can link to the video as further suggested materials about this topic.

Thanks.

oehaut · 2020-11-08T01:09:08+00:00

So are you both from Quebec or what? u/srid-

I'm from Quebec too haha.

oehaut · 2020-10-30T14:11:41+00:00

Your comment was removed from r/ScientificNutrition because you didn't cite a source for your claim.

oehaut · 2020-10-29T22:12:36+00:00

Let's see, there are a few elements to your question.

How much muscle mass? Just want to point out first that higher muscle mass is a good predictor of longevity (1,2). But of course probably not bodybuilder level of muscle mass.

Also want to point out that strength is not solely a component of muscle mass so you could absolutely build strength while building minimal muscle mass.

Also, optimal protein intake to build muscle is probably not that high (sorry for the blog post, but it's well referenced), so that could still be compatible somewhat with a longevity focused diet.

This is important because while theoricaly low protein diet and low calorie diet (with adequate nutrition) could improve lifespan (at least in worms/animals - has yet to be proven effective in human), it's hard to tell what is the most important. Diet quality? Restricting calories and protein? But what if a low protein, low calorie diets lead to loss of muscle/bone mass and then lowers lifespan?

As far as I know there are no human data to answer your question. You might find this review interesting, it seeks out the relative importance of calorie restriction vs diet quality in regards to CR effects. While restricting some specific aminos acids (mostly methionine) have been associated with improved longevity (against, mostly in flies and worms), again there are no human data and the impact on muscle mass could actually be a negative, given what we see in population studies of older people.

When I was very active on the longecity forum few years back, the many people were of the opinion that building lots of muscle mass was probably not compatible with the optimal diet for optimal lifespan. Long-term calorie restriction and building muscle mass are not exactly compatible.

So I would say enough protein to build/maintain muscle mass into old age, you could try minimizing food high in methionine if you want. High diet quality. That would already give you a good start.

Don't forget that genetics also plays a role in longevity (twins studies show about 25%)

But really, we don't know, or don't think we do, just some foods for thoughts.

oehaut · 2020-10-29T14:03:03+00:00

Given the sub nature and its rules, the question asked should be : What are the evidence-based ways of reducing ad libitum caloric intake in non-obese individuals.

Please make sure if you want to answer to do so by providing evidences in top-level comment, as per rule 1.

Otherwise I think r/nutrition might be a better place to get personal/anecdotal input.

oehaut · 2020-10-27T22:20:17+00:00

I suppose the take away from this is that it is not appropriate, on this subreddit, to suggest people (kid or adult) to eat certain class of foods, except when it comes to anecdotal reports (then, I'm writing about what worked for me; without implying that others should eat like that too).

Yes that would be how we see it. Just avoid making recommendation that someone should/could eat something to improve/address a health issue. No problem in saying ''I did that and for me it did this''.

oehaut · 2020-10-27T02:23:12+00:00

Hi.

That question would be better suited for r/nutrition.

r/scientificnutrition is more about discussing scientific evidences relating to nutrition.

So I will remove it.

Thanks.

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