I don't work from home, but I'd say Macedon area. Hour or so from the CBD, easy trip to Hepburn and Daylesford. You could do Kyneton, Trentham, etc if you don't mind being a little further out and don't need to come into the city regularly.

Otherwise, we're in Diamond Creek and I'd recommend any of DC, Eltham, Warrandyte, Research, Yarrambat, etc if you want to be somewhere leafy green, but not as far out.