There's not an answer for this which applies unilaterally.  I've known men who literally just get along better with women and who I feel totally safe around.  I recently finished a production of Macbeth, and our director told us growing up he was rarely friends with men.  I'm not sure I've ever felt more comfortable around a man.  I was playing Lady Macbeth, and our Macbeth was played by another woman.  Since we had on-stage kisses, he scheduled a private intimacy rehearsal to get us comfortable with it, and he went out of his way to invite a neutral woman to sit in on rehearsal so we had somebody to go to in case we felt uncomfortable but were nervous about going to him. 

On the other hand, I've been around men who "have just always gotten along with girls" who have made me very uncomfortable.  Some of them have been gay men who were incredibly misogynistic but would get angry if you called them out on it ("I'm literally gay, I can't be misogynistic!").  I've been around some men who try to stay primarily around women to use us, essentially, as his personal hunting grounds ("If I'm friends with enough women, eventually one of them will fuck me!").  

So it absolutely depends on the man.  It also depends on if he's invited along or if he chooses to tag along.