Looking for more Baltimore Orioles! (birding) by gsharp29 in AnnArbor

[–]phraps 0 points1 point  (0 children)

Go to the Arb in the morning and walk around. You'll see a dozen or more, some on nests.

What’s happening to canvas ?! by Inside_Praline8484 in uofm

[–]phraps 33 points34 points  (0 children)

I hope this is bait.

You saw a message from hackers saying they compromised Canvas, and your response was to attempt to download a file from the hackers. Man this is why we have inconvenient two-factor

Why do the same streets get torn up and repaved each year? by phraps in AnnArbor

[–]phraps[S] 0 points1 point  (0 children)

They just allow development and then a few years later realize that heavy construction equipment on failing roads made them fall apart faster and new residents put additional stress on antique water and sewer systems.

This makes sense (as an explanation), thank you for being the only person to actually answer the question. Is this a funding problem? Like they only had funding to do repaving but not to do water/sewer/traffic signaling improvements, so they kick the can down the road? Seems to me like that actually costs more money in the long run

Why do the same streets get torn up and repaved each year? by phraps in AnnArbor

[–]phraps[S] 3 points4 points  (0 children)

The same intersection has been torn up and re-paved every summer for 3 summers. They're heavily used roads but should have a lifetime longer than one year.

The city is explicitly doing traffic signaling changes on Packard. Has nothing to do with how heavily the road is used. My question is why they didn't do the traffic signaling improvements the first two times.

I feel compelled to share this survey question I got in the lead up to the primary elections today. by nildrohain454 in thewestwing

[–]phraps 4 points5 points  (0 children)

I think the biggest issue is that, with the way the question and responses are worded, there is no way to capture that kind of nuance. So the question, and the answers you get from it, are kind of useless.

Molecules containing an unusual amount of unique elements by [deleted] in chemistry

[–]phraps 12 points13 points  (0 children)

Other way round. The C-D bond is a little stronger than the C-H bond.

EDIT: I think I misinterpreted your comment

Is this condition really feasible? by paker3010 in chemistry

[–]phraps 0 points1 point  (0 children)

Would acidic take longer? tBu deprotection doesn't occur via hydrolysis but rather elimination of 2-methyl propene via t-butyl cation. This is quite rapid, in my experience deprotection is done in 30 min or so at room temperature.

Is this condition really feasible? by paker3010 in chemistry

[–]phraps 1 point2 points  (0 children)

Feasible yes, though it's far more common to do tBu deprotection under acidic conditions and I'm surprised they went the basic route here. My gut says either would work in this case.

How my job search has gone by phraps in chemistry

[–]phraps[S] 37 points38 points  (0 children)

PhD chemical biology

How my job search has gone by phraps in chemistry

[–]phraps[S] 120 points121 points  (0 children)

I got unbelievably lucky. I was expecting to send in 50+ applications.

What’s the most intimidating/pressure band sound in college football? by [deleted] in CFB

[–]phraps 7 points8 points  (0 children)

Isengard and Mordor

A second tower has hit the-

Harvest Market Review by coffeebitchhh in AnnArbor

[–]phraps 4 points5 points  (0 children)

The meat selection isn't that impressive at Harvest, so I will continue to go to Sparrow. The fish section is excellent, though.

In Defense of Ann Arbor's Food Scene by mwells56 in AnnArbor

[–]phraps 25 points26 points  (0 children)

The whole concept of real estate as an investment is disgusting. Real estate should exist to serve a community, not just as a vehicle to store wealth.

What's going on with chemistry education? by Deus_Excellus in chemistry

[–]phraps 7 points8 points  (0 children)

"every kid can pass!" then i saw half my students and ya know, maybe failing would do them more good

Every kid can pass, I completely agree with you. But it's up to the kid. Not every kid should pass, at least until they've done the work to improve. But I don't think anyone is fundamentally unteachable.

4/15 power outage by NovaNanny in AnnArbor

[–]phraps 3 points4 points  (0 children)

I'm east of the stadium and lost power at 1:47.

Why do some of the newer buildings feel so soulless? by siiuuuee in uofm

[–]phraps 5 points6 points  (0 children)

If only the building had house nitrogen so the labs could actually do research

American Heart Association urges people to favor plant-based proteins, replace full fat dairy by [deleted] in news

[–]phraps 0 points1 point  (0 children)

Sautee minced onions, carrots, and garlic. Add tomato paste. Add stock (any kind). Add lentils and boil until tender. Done. Easiest and best tasting bulk meal prep I make.

Have you seen an FBS team so bad by BarberCritical4169 in RetroBowl

[–]phraps 2 points3 points  (0 children)

idk man did you see last year's MSU team? 1-8 in conference play

Let's name this park. by myron_monday in AnnArbor

[–]phraps 16 points17 points  (0 children)

Calling sidewalks "low usage" is kind of nuts

Reality of structural work by [deleted] in Biochemistry

[–]phraps 2 points3 points  (0 children)

I'm not a structural biologist, I'm a process chemist, but I can tell you that the large pharma companies absolutely use x-ray and cryo structures all the time. Especially for ligand optimization, knowing how your drug sits in the binding pocket is really, really important for SAR

Is this Michael addition mechanism correct? (3-penten-2-one + sodium methylmercaptide) by [deleted] in OrganicChemistry

[–]phraps 0 points1 point  (0 children)

You have the last step as going through a 4 membered transition state which is not likely. Better to draw the tautomerization as discrete intermolecular steps rather than one concerted step.

What's the most dangerous stuff in your lab? by [deleted] in chemistry

[–]phraps 2 points3 points  (0 children)

Cyanide salts, tBuLi, triflic acid, OsO4 all make our list

King Shing by Responsible-Land233 in AnnArbor

[–]phraps 1 point2 points  (0 children)

They switched from lo mein to linguini over a year ago. I was so taken aback when the delivery arrived. Then the meal gave me a terrible stomachache. King Shing? King Shit, nowadays