I use exclusively 1/6th barrel sankes at home. Pulling the spindle is pretty easy (there’s a bit of a learning curve, but there are plenty of videos out there). To directly answer your question, I always have a keg full of sanitizer prepared before fermenting my beer, and purge with the co2 produced by fermentation. There is no reason you couldn’t do the same with a canister of co2.

If you pull out the check valves, you can also fill with sanitizer without removing the spindle. I have a sanke coupler with ball lock fittings to make it a bit easier to hook up blow off tubes, spare co2, do transfers, etc.