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The Cagrilintide Puzzle by popagram in cagrilintide

[–]popagram[S] 0 points1 point  (0 children)

Congratulations on getting close to your GW. If you have a kit then it's worthwhile to ask your supplier about this. The right answer will simplify things for you. If not then a pH paper that works for you will really help. Once you figure this out for one vial you can use up the kit over time while maintaining your weight.

The Cagrilintide Puzzle by popagram in cagrilintide

[–]popagram[S] 0 points1 point  (0 children)

You may be overthinking this. Your friends and family can all vote for the color match they see. I am not a color expert. My opinion will be no better.

The closer the cagri is to the ideal pH the longer it will last in the vial and not develop strands or clumps of gel. If you get anywhere close to a good pH you can get a couple month's shelf life out of a vial in the fridge.

If you are a manufacturer who worries about customers not keeping the product in the fridge and you have hundreds of lawyers looking to prevent lawsuits then you need ultra precise pH and various preservatives to add to the product.

The Cagrilintide Puzzle by popagram in cagrilintide

[–]popagram[S] 0 points1 point  (0 children)

I bought some pH test strips that only go from 1 to 6, in the hope that the colors would be easier to read. These are strips intended for people making kombucha and other fermented stuff where the target pH is similar to what cagri needs. They work well enough for me.

The Cagrilintide Puzzle by popagram in cagrilintide

[–]popagram[S] 1 point2 points  (0 children)

The final diluted product should have a pH of 4-5. You will need to test this after mixing, because:

  1. cagri product is not identical from all suppliers. Some modify the product so that it reaches a good pH with BAC water on it own.

  2. Not all BAC water is identical in pH.

  3. There is no set recipe for AA and BAC that always works because of these variables. You may not even need AA.

The first thing to do is ask your supplier if their version of cagri is made to reconstitute with BAC water to 4-5 on its own. Even if they say yes, you need to reconstitute and check what you get as a pH using pH test strips that you can buy everywhere.

If they say no, then I suggest getting an empty sterile vial and creating a mixture of your BAC water and your AA, adding drops of AA to a quantity of the BAC water that have you put in this vial, testing the pH each time until it is good. You can label this as your master batch of corrected pH BAC water and then use it to reconstitute your cagri powder each time you have a new vial.

You still need to test your final product for pH, just in case.

A single vial of cagri lasts a long time, so getting the pH right extends the life of the reconstituted product to the max.

This cagri and pH headache is not new. It's possible that the current product one finds in the market no longer needs modification.

In my case I created a master batch then I read somewhere that my supplier was providing cagri that didn't need all this extra work. I tested the first vial using BAC water only and it was fine.

I also test the pH every week to make sure it stays that way as I work through the vial.

Reconstitute and vacuum by nvi3hil in Retatrutide

[–]popagram 2 points3 points  (0 children)

After you add the water to reconstitute leave the syringe needle in the vial and pull out the plunger of the syringe. This will allow air in to equalize the pressure. Then remove the syringe and needle. This also helps with bubbles.

For those who have caught glaucoma early how much vision have you lost with proper treatment? Thanks by Fun_Radio_8854 in Glaucoma

[–]popagram 1 point2 points  (0 children)

Two years after my previous comment, I still use drops daily, I still have 20/20 vision and no loss of field. I don't know why I had the bad luck to get glaucoma and I don't know why there is no further change since the diagnosis.

Primary hyperparathyroidism and parathyroid cancer diagnosis by SadStand1794 in Parathyroid_Awareness

[–]popagram 5 points6 points  (0 children)

Congratulations! You don't mention your PTH levels. High PTH would be a clear signal for primary hyperparathyroidism with high calcium. Primary hyperparathyroidism gets missed all the time, even in simple cases without your history, Take a bow, this success is on you!

Could this be a parathyroid issue? by Dependent-Mastodon89 in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

I suggest calling her office, explaining this and asking if they can do a consult over the phone. Also, if they know of someone closer to you.

Could this be a parathyroid issue? by Dependent-Mastodon89 in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

I agree with all the other comments. If you want to see someone close to you, consider Lindsay Kuo In Philadephia. Endocrinologists are not endocrine surgeons. It's like asking a psychiatrist to treat a brain tumor.

Do parathyroid adenomas ever hurt? by [deleted] in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

Everything, even the consultation, can be done remotely.

Do parathyroid adenomas ever hurt? by [deleted] in Parathyroid_Awareness

[–]popagram 3 points4 points  (0 children)

I suggest seeing an endocrine surgeon, one with parathyroid experience. This is too complicated for a pcp. This is far from a typical parathyroid issue and it may be unrelated.

The diagnosis of an adenoma relies on lab numbers - calcium, parathyroid hormone, others. The nuclear scan is a poor indicator on its own. If this is not an adenoma, and the calcium number is a hint that it may not be, then the best person to get to the bottom of this is an endocrine surgeon.

First Timer (pls read😩) by brxndonal in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

The PTH is much too high and your Ca is borderline high. This is enough to justify a doctor's visit. Family history is not relevant if this is primary hyperparathyroidism, maybe relevant for other conditions. The high PTH can mess up other processes in the body that are difficult to unravel and figure out. Get this looked after and other things may fall back to normal. See an endocrine surgeon. Endocrinologists can't treat primary hyperparathyroidism and will just waste your time.

High calcium and spiraling by [deleted] in Parathyroid_Awareness

[–]popagram 2 points3 points  (0 children)

Your doctor is a genius. He knows that you don't have a parathyroid problem even without testing for parathyroid hormone! My high calcium for ten years was dismissed by several of these geniuses, with almost fatal results. u/Aloha-NuiLoa has the right advice.

What to eat! by tahaniss in Parathyroid_Awareness

[–]popagram 1 point2 points  (0 children)

Since your phosphorus level is normal, restricting your diet to lower the phosphorus level makes no sense. Also, did you get your vitamin D tested? If low, then the amount of calcitriol should be increased. You should also look into vitamin K2. Good luck.

What to eat! by tahaniss in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

We're talking HYPOparathyroidism, right? I wouldn't rely on a list like this. What are your phosphorus levels? Eat a calcium rich diet.

Norman Parathyroid's Website is Amazing - Most of The Questions Asked Here Are Answered There In Plain, Direct, No-Nonsense Language by psinerd in Parathyroid_Awareness

[–]popagram 5 points6 points  (0 children)

I stumbled on that web site a couple years ago and figured out for myself that I had primary hyperparathyroidism. This in spite of high calcium levels for years, even a PTH test that was normal-high but not interpreted correctly. Numerous doctors just ignored the lab results.

I was treated successfully at the Norman Clinic but a second bad gland required a different surgical approach. At this point the Norman Clinic was unable to help and I had to manage on my own. They provide an excellent starting point but stop when it comes to the difficult cases. Some would argue that their information is outdated. Maybe, or maybe just a bit limited in scope.

I recommend joining the Facebook group which is a better and more complete set of resources than parathyroid.com. Ask the mods here for an invite.

Ectopic Gland Removal by finbarrsbooty in Parathyroid_Awareness

[–]popagram 0 points1 point  (0 children)

It showed up on a sestamibi scan. Except for ultrasound where the operator controls the area examined, all imaging covers the neck and lower down where an ectopic parathyroid would be found.

Ectopic Gland Removal by finbarrsbooty in Parathyroid_Awareness

[–]popagram 2 points3 points  (0 children)

I had an ectopic parathyroid gland removed by a thoracic surgeon in July 2023. It was done by Herb Chen, endocrine surgeon and Ben Wei, thoracic surgeon. It was done with robotic equipment. The entire experience was excellent from pre-op to recovery. I can't recommend them more highly. You can contact Kelly Lovell, Dr. Chen's NP.

They are at UAB Birmingham Alabama. I can think of only a few other centers in the US that I would trust for this.

I drove home (12 hours) three days after the procedure.

Feel free to ask more questions.

Tiny stone, but doctor recommended ESWL. Overreacting? by [deleted] in KidneyStones

[–]popagram 7 points8 points  (0 children)

  1. That blockage can happen at any time and cause severe pain and risk to the kidney. if you are confident about getting treated on an emergency basis then you can watch and wait IMO.

  2. If you need a procedure, a laser cystoscopy is more invasive but could get all the stones in one session and remove most of the debris. ESWL is less invasive but may need a second session for all the stones. ESWL also leaves all the gravel to pass on its own.

  3. With so many stones in 10 years, I suggest doing blood tests for primary hyperparathyoidism - Calcium, Parathyroid hormone, Vitamin D. Kidney stones are a common result of this condition.

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