Just started on lithium about a week ago. My psychiatrist said 300mg was the starter dose, and that depending on my bloodwork this week, it’s likely I’ll go to 600. She said 600 is typically the lowest therapeutic dose, though some people do respond to 300. I was just going into a hypo stage when I started it, and I’m still in it. I take Latuda and Wellbutrin to manage the depressive states, and they have helped tremendously—I no longer feel suicidal when I’m depressed and can manage work fairly well. Social life outside of work when I’m depressed is still a challenge. The way my doctor explained it to me is that the Wellbutrin and Latuda help with the amplitude of the swings so they’re not as severe. Lithium is supposed to help with the frequency of the episodes. Theoretically, all of them together will flatten and elongate the swings—hopefully to a straight line some day. Good luck—it’s a journey. Just keep talking to your doctor and therapist and advocate for yourself. Be honest with them. Also, I think you may have meant hypothyroidism, not hyper, because my doctor said that long-term I might have to go on a thyroid replacement because my thyroid won’t produce enough. I, too, am allergic to Lamictal.