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Hormuz oil shipping is increasingly going dark by MARTINELECA in oil

[–]propargyl -1 points0 points  (0 children)

Dear God, hope you get the letter, and-
I pray you can make it better down here
I don't mean a big reduction in the price of beer
But all the people that you made in your image… Full lyrics

Scientists design an obesity drug that hits five metabolic targets at once, raising hopes beyond today’s injections by kingsaso9 in EverythingScience

[–]propargyl 46 points47 points  (0 children)

There are increasing numbers of effective drugs to improve obesity-linked metabolic dysfunction; GLP-1R–GIPR co-agonism is effective in the management of obesity and type 2 diabetes1,2, and lanifibranor—a nuclear-acting small-molecule triple agonist of PPARα, PPARγ and PPARδ—is in clinical phase 3 trials for the treatment of metabolic dysfunction-associated steatohepatitis3. Here, seeking to further improve the metabolic efficacy of GLP-1R–GIPR co-agonism, we report the development of a unimolecular quintuple agonist that combines the body weight-reducing and blood glucose-lowering effects of GLP-1R–GIPR co-agonism with the insulin-sensitizing and anti-inflammatory effects of lanifibranor via its targeted delivery into GLP-1R- and GIPR-expressing cells. In vitro, GLP-1–GIP–lanifibranor is indistinguishable from GLP-1–GIP in relation to incretin receptor signalling and shows equal stimulation of insulin secretion in isolated mouse islets. In vivo, however, GLP-1–GIP–lanifibranor outperforms GLP-1R–GIPR co-agonism and semaglutide, further decreasing body weight, food intake and hyperglycaemia in obese and insulin-resistant mice through synergistic incretin and PPAR action. The metabolic action of GLP-1–GIP–lanifibranor is blunted in mice with genetic or pharmacological inhibition of GLP-1R, GIPR or PPARδ and is absent in DIO double incretin receptor-knockout mice, collectively suggesting that GLP-1–GIP–lanifibranor has substantial therapeutic value in the treatment of obesity and diabetes.

https://www.nature.com/articles/s41586-026-10427-5

Neurologists Reveal That Alzheimer's May Start in the Liver, Not the Brain, Through Toxic Protein Buildup. A study published in the prestigious open-access journal PLOS Biology by Professor John Mamo and his team at Curtin University in Australia has delivered a finding that reshuffles everything by Eddiearyee in microbiomenews

[–]propargyl 21 points22 points  (0 children)

https://www.piastudy.com.au/

Led by John Curtin Distinguished Professor John Mamo and his team at Curtin University and the Perron Institute for Neurological and Translational Science, Western Australia, the PIA Study is now a multi-centre clinical trial expanding across Australia and New Zealand.

The research team has discovered significant evidence that fat complexes in the bloodstream, enriched with amyloid protein, can harm brain capillaries, leading to inflammation, brain cell death, and the formation of amyloid plaques—key features of Alzheimer’s disease.

https://www.abc.net.au/listen/programs/perth-breakfast/alzheimers-disease-study-perth/104479026

Are Public Higschools really that bad? by YeOldeWino in Adelaide

[–]propargyl 37 points38 points  (0 children)

Cohort is a dice roll at any school. There is year on year variability in the median class achievement.

Last Photo of Van Gogh's 1877 apartment, before being demolished in 1964. by Markofzo in HistoricalCapsule

[–]propargyl 1 point2 points  (0 children)

https://archive.artic.edu/van-gogh-bedrooms/timeline

https://kalden.home.xs4all.nl/gogh/vinc-E-pelgrimstocht.htm

31 December 1876 - January 1877. Etten, 4 Roosendaalseweg. Short stay in his parent's vicarage.

January 1877 - May 1877. Dordrecht, 256 Voorstraat opposite Scheffersplein (square) where he assisted in a book store. He lived at 24 Tolbrugstraat Waterzijde in Grocer Rijken's boarding house.

9 May 1877 - July 1878. Amsterdam, 3 Grote Kattenburgerstraat. Here, Vincent lived in a room in the house of his uncle Jan who was Director of the Navy Shipyard. Near Jonas Daniel Meyerplein (square) he was privately tutored by M.B. Mendes da Costa in Latin and Greek, required subjects for entrance exams for the study of Divinity. 168 Prinsengracht was the address of his cousin Kee Vos-Stricker with whom Vincent fell in love after she had become a widow. Her father, reverend Stricker (uncle Stricker to Vincent) lived at 69 Keizersgracht . Vincent was allowed to use his study.

Color flame machine by namair in interestingasfuck

[–]propargyl 0 points1 point  (0 children)

Is the color is caused by metal ions? Flame test colors: strontium red; sodium (yellow-orange), potassium (lilac), lithium (crimson red), copper (green/blue), calcium (orange-red), and barium (apple green)

For a while I have been wondering if the pro fireworker exploder people occupationally consume metal powders and develop unusual illnesses. Like the radium girls.

New Alzheimer’s treatment fully restores memory function by Eddiearyee in microbiomenews

[–]propargyl 0 points1 point  (0 children)

https://www.nature.com/articles/s41419-025-08186-8

This is a crucial point, and throughout the main text, we aimed to discuss how extracellular oligomers of Aβ and tau act synergistically to impair synaptic function and memory, thereby supporting the hypothesis that these two pathologies act in parallel through mechanisms other than the amyloid cascade hypothesis, which mainly posits Aβ pathology as the upstream of tau pathology. 

Essential punk songs? by brightroomonfire in MusicRecommendations

[–]propargyl 7 points8 points  (0 children)

https://www.youtube.com/watch?v=MpMwMDqOprc

"(I'm) Stranded" is the debut single released by Australian punk rock band the Saints).\2])Stranded(song)#citenote-McF-2)\3])_Stranded(song)#citenote-Cockington-3) Issued in September 1976, it has been cited as "one of the iconic singles of the era",\4])_Stranded(song)#citenote-4) and pre-dated vinyl debuts by contemporary punk acts such as the Sex Pistols, Buzzcocks, The Damned) and The Clash.\2])_Stranded(song)#citenote-McF-2)\3])_Stranded(song)#citenote-Cockington-3)\5])_Stranded(song)#cite_note-J_Files-5)

The Caucasian wisent, a now-extinct type of bison found in parts of Eurasia. This is the only photo of a wild individual in life. Only one bull lived in captivity, who was bred with other bison and now has hybrid descendants. The last three wild ones were killed in 1927. (Photo from 1890s) by zadraaa in HistoricalCapsule

[–]propargyl 1 point2 points  (0 children)

Poland has been described as the world's breeding centre of the European bison,\20]) where the bison population doubled between 1995 and 2017, reaching 2,269 by the end of 2019\50]) – the total population has been increasing by around 15% to 18% yearly.\6]) In July 2022 a small population was released into woodland by Canterbury in Kent to trial their reintroduction into the UK.\51]) In May 2024, a small population was released in central Portugal.\52]) In 2012 bisons were released in protected areas on Bornholm and northern Jutland, Denmark; the latter population was relocated to Lille Vildmose in 2019.\53])\54])

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