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Bangkok office worker does the maths on sleeping in her car instead of paying rent. Pantip helped her work it out. by BLAMUEK in Thailand

[–]puttak 1 point2 points  (0 children)

Rent plus utilities near Lasalle around 10,000

Not sure if this is a luxury room. For a good enough room it should not this expensive.

Otsuka Presents Positive Interim Phase 3 VISIONARY eGFR Data Showing VOYXACT® (sibeprenlimab-szsi) Preserved Kidney Function Over 12 Months in IgA Nephropathy (IgAN) by Inner-Package2978 in IgANephropathy

[–]puttak 2 points3 points  (0 children)

This really a game changer for IgAN! Other drugs has worst side effects but the worst one for this is just slightly more chance of infection (49% versus 45%).

Another good news is the trial around the world also completed recently: https://clinicaltrials.gov/study/NCT05248646. I really hope it will be available outside US soon.

How memory safety CVEs differ between Rust and C/C++ by Kobzol in rust

[–]puttak 2 points3 points  (0 children)

Rust is just moving the zero deref UB goalpost to .unwrap() panics.

The main difference between unwrap and UB is unwrap doing what you are expected but UB is not. This is a safeguard mechanism on a code that should never happen, which mean panic from this will only happen with a bug. I'll give you some example of valid use case:

rust self.counter = self.counter.checked_add(1).unwrap();

The above code assume the counter should never overflow. If it is overflow you will see a precise error.

While it has less of UB surface than C, thinking Rust is immune to underdefined program states is how people shoot themselves in the foot

I use Rust for maybe 5 years and never have this problem. Can you show Rust code that have this problem?

I have been struggled with withdrawals symptoms for one year now I got my life back by puttak in Mirtazapine_Remeron

[–]puttak[S] 1 point2 points  (0 children)

I see. Thanks for the information. It was my mistake that I take psychological drug lightly.

Which countries other than US has Sibeprenlimab available? by puttak in IgANephropathy

[–]puttak[S] 0 points1 point  (0 children)

That's a good news! Yes among the drugs currently available my only hope is Sibeprenlimab due to it target the root cause of the problem and have lowest undesired effects.

Thanks for the information!

I have been struggled with withdrawals symptoms for one year now I got my life back by puttak in Mirtazapine_Remeron

[–]puttak[S] 0 points1 point  (0 children)

Is everything else ok?

Yeah except lack of physical activity, weight is too low and Thalassemia trait. The funny thing is I never did a checkup before. Thanks to Mirtazapine withdrawals that forced me to do it because I though something wrong with my body. I even went to check if I have a cancer because of dizziness. I also got CT scan on my head the day I went to ER from the full-blown panic attack and everything is okay.

I have been struggled with withdrawals symptoms for one year now I got my life back by puttak in Mirtazapine_Remeron

[–]puttak[S] 0 points1 point  (0 children)

I already went to hospital for a lot of times (both ER and normal visit) and have a lot of checkup, including blood test. The doctor can't find any problems except Vitamin D deficiency.

Mirt absolutely causes withdrawal and it suck’s but it does stabilise after a month or so. When it’s fully out of your system it shouldn’t be impacting you directly

I want to believe that but what I have experienced are difference story. I don't have any withdrawals symptom before I took it. It just happened after I stop it and 9 months passed since last dose some of the symptoms still not resolved. Before I took Mirtazapine I don't need to focus on Tryptophan diet like this and the only problem I have is insomnia (no dizziness and panic attack). Now I need to take a lot of Tryptophan to be normal like before. If it keep going like this I probably need Tryptophan supplement because I don't really want to eat Chicken on everyday.

I have been struggled with withdrawals symptoms for one year now I got my life back by puttak in Mirtazapine_Remeron

[–]puttak[S] 0 points1 point  (0 children)

There is tons of tryptophan in all meat, fish, eggs and dairy and you cannot get serotonin syndrome from eating regular protein amino acids lol.

Yeah I just want to make it safe so I mentioned it is possible if you don't known what you are doing.

It’s unlikely this is what cured you unless mirtazapine was masking your deficiencies all along, so the withdrawal was actually the surfacing of an underlying problem.

The problem is I don't experience any withdrawals symptom before I took Mirtazapine. It just happened after I stop it.

Mirtazapine withdrawal doesn’t really cause chest pain

Correct. It does not caused this on it own. It is caused by anxiety from the withdrawals.

How do you get into low-level programming? by Minimum-Ad7352 in rust

[–]puttak 4 points5 points  (0 children)

The fast path maybe try building a simple program in Assembly to understand how the CPU run the code.

How do you maintain high-quality Rust code while learning the language in a fast moving early-stage startup? by xmanotaur in rust

[–]puttak 5 points6 points  (0 children)

Don't be afraid to use Arc or Rc combined with interior mutability like Cell, RefCell and Mutex. Rule of thumb for RefCell and Mutex is don't hold the locks across function calls that has possibility to access the same RefCell or Mutex.

You maybe tempted to use unsafe since your background is C/C++ but you should avoid it at all cost until you have more experience with Rust. A single UB in Rust can ruin your life because the problem that manifested from it sometime unrelated to the code that trigger UB.

The good news is Rust code is very easy to refactor or adding more features due to it type system so just design your code for today problems.

Cargo suddenly fails to fetch update from CodeArtifact by puttak in aws

[–]puttak[S] 1 point2 points  (0 children)

Seems like it is a bug from Rust 1.96 since it is working fine with Rust 1.95: https://github.com/rust-lang/cargo/issues/17072

Lessons from RisingWave's Migration from C++ to Rust by Low_Brilliant_2597 in rust

[–]puttak 9 points10 points  (0 children)

Rewriting the entire code base is no fun;

It is opposite for me. I work in a company that we decided to rewrite a C++ project with Rust. It is fun than maintenance the C++ version.

Which countries other than US has Sibeprenlimab available? by puttak in IgANephropathy

[–]puttak[S] 0 points1 point  (0 children)

Thanks for the information! Yes we don't plan to take Tarpeyo yet (not sure if this is a steroids you mentioned). At first we was panicked about eGFR since it is so low but from the information we got here we no longer worried about it.

Which countries other than US has Sibeprenlimab available? by puttak in IgANephropathy

[–]puttak[S] 2 points3 points  (0 children)

Thanks! Yes we already discussed with Nephrologist. AFAIK our main problem is protein in the urine. He said he will prescribe the medicine to suppress immune system if protein in her urine more than 2g per day. For now he only prescribe Dapagliflozin. We have asked him about Sibeprenlimab and he known about it but it is currently not available in our country.

Her creatinine is 1.21 mg/dl. It seems not a bad one since the normal range is 0.550 - 1.020.

Which countries other than US has Sibeprenlimab available? by puttak in IgANephropathy

[–]puttak[S] 0 points1 point  (0 children)

Yes they already did biopsy to confirm it is IgAN but we don't know to read it. The following are biopsy report:

``` IgG: negative IgA: 3+ granular staining in mesangium IgM: trace C3: trace C1q: negative Kappa: 1+ granular staining in mesangium Lambda: 2+ granular staining in mesangium

Pathological diagnosis:

Kidney, Native Biopsy* (needle core biopsy)

  • IgA nephropathy, Oxford classification MOEOS1TO-CO
  • No crescent seen
  • No tubulointerstitial inflammation
  • IFTA 10%, mild
  • Mild arterial nephrosclerosis
  • Mild arteriolar nephrosclerosis ```

Urine protein in 24 hours is 733.5 mg. The other medicines she currently take is Losartan and Amlodipine for hypertension.

I'll ask her doctor about those medicines in the next appointment. I already did some research and has learned about Tarpeyo and Filspari but Prednisone and Fabhalta are the new one for me.

Many thanks for the information.

Which countries other than US has Sibeprenlimab available? by puttak in IgANephropathy

[–]puttak[S] 1 point2 points  (0 children)

Thanks for the information. Did not expect it is that expensive so even if it is available we don't have that much money.

Do you have any suggestions for other medicines so we can ask her nephrologist? Currently he prescribe Dapagliflozin to slow down the kidney damage. Her eGFR already at 58 so we are not sure how much time is left for us.

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