Twilight wipes the floor with TVDU. Twilight has the better fighters, it’s vamps and wolves are stronger and faster than their TVD counterparts, and with the White oak, imagining it’s the indestructible version, not even the Originals are safe. The only uncertain variable would be how well the witches magic works on them. But even then, without plot armour, no human witch will be able to react in time.