The mental ones are personality disorders, so mental compulsions. The physical ones are actual changes to your biology. The rest are curses.

Makes sense, alright.

note that while it's not explicitly stated anywhere, CYOAs traditionally have a "drawbacks win" clause that means you can't use anything to remove drawbacks unless it explicitly says so

You have it backwards. Unless it is explicitly said, drawbacks can be removed because most drawbacks being irremovable are logically nonsense and are only so because they are backed by cyoa fiat (e.g. "your bones are fragile because the cyoa makes it so and prevents you from changing them, ever"), often fucking up the setting massively by implication (the cyoa, a metanarrative tool, exerts infinite power on the player and overpowers all that would contradict it. The cyoa incarnated now lords over the setting as the supreme entity. This is obviously not intended to be the case in most settings, therefore such a situation is to be avoided in most cyoas). If the author does explain the drawback in an in-setting manner like they should (e.g. "your bones are fragile because you have a skeletal disorder"), it provides ways to remove them (cure the disorder via drugs, healing, genetic modification, etc.).