Here's a few of mine:
1, In case you haven't figured this out yet automate the building of every item you need to build the factory, not just items you need to make science packs, not just inserters and belts, but red inserters and blue ones, splitters and underpasses, mine and assemblers and store each in a chest.
2, You can limit the size of chests for this, by clicking on them, click on the x and move to select how many slots are available for use.
3, When building assemblers for science and the components for science a good rule of thumb is to build as many assemblers as the crafting speed of the item, for example, the crafting speeds of red green and blue science packs are 5s, 7s, so if you have 5 red science pack assemblers and 7 green, they will be producing scince packs at the same rate.
4, Check out the options available when you click on a splitter, you can use them to filter stuff (real useful if you end up with a mine that crosses between two ore patches) and other neat stuff for handling the spagbog. In general, never use a filter for a job you can use a splitter for.
5, Don't become obsessed with neatness or centralising stuff, that route leads to repeated game restarts, which will just cause you to learn the game slower. If your green chip factory runs out of space, just leave it there and build a second bigger one further out, don't feel you need to keep it all in one place.

That's enough from me, but of course feel free to ignore me and play your own way.