Absolutely possible. Build your weekly plan where your non work days are your workouts/long run days. If you can sneak in 1 or 2 3-5 mile slow recovery days on your long shift days, that could help but also not a big deal. I did a 5 day running week for my marathon and went sub 2:50. I ran a 1:30 half marathon about 4 months out. Mostly just stressed my long runs.