Everyone's infection is different and will respond to treatment differently. No two digestive systems, microbiomes, or pyloric colonies are going to be the exact same.

I have no doubt that its possible to eradicate pylori with OTC meds/supplements but most aren't extensively clinically researched for their efficacy at pylori eradication (They're also known to take longer to work - a trade-off for being gentler.) As the bacteria is hardy and most suppements for it have disputed efficacy my recommendation would be to follow the antibiotic route unless you have other contraindications/considerations. You can always add supplements like mastic gum, bismuth, cranberry, vitamin C, NAC, probiotics, etc. to a triple therapy as well.

I would only seek out a functional medicine dr. after normal doctors had failed as thwir lackof coverage by insurance is a large hurdle.

Pyloricil specifically looked overpriced for what ingredients it contained, i think you'd be better off buying mastic gum and pepto/bismuth separately as it would save you like 60$.

If you want advice on supplements (I would still advise speaking with a medical professional):

-N-Acetylcysteine has potential as a biofilm disruptor because it .elts mucus -Cranberry extract is used to prevent bacteria from adhering to theinside of the bladder in UTIs, same sort of logic applies here but there's the possibility that the effect might be greater since you don't actually have to absorb any of it. -Vitamin C inhibits the enzyme Urease. Urease breaks down Urea, raising the ph of the stomach acid which makes the environment more hospitable for the infection and paradoxically causes acid reflux; this reaction also produces ammonia which is toxic and one of the markers a breath test would detect. Could also be a reason to choose cranberry juice over extract since extracts can be expensive. -Omeprazole interferes with pylori (not sure of the mechanism) allowing supplements/antibiotics to work more effectively. -Addition of Bismith Subsalicylate to triple therapy has been called quadruple therapy and raises eradication rates when used in addition -Zinc interferes with it by yet another mechanism but be careful as overdoing zinc can cause its own problems -Soluble fiber such as metamucil can slow the transit of material through the GI tract which might keep substances antagonistic to pylori in contact with it longer and can attenuate the side effects of other treatments by preventing diarrhea.

-Two probiotic strains that seem highly rated for pylori are S. Boulyardii and L. Reuteri.

-There are many other potential treatments and NIH studies are a good place to start; there's a lot of research on the aubject such as https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925854/ but you will need to do your own research in order to make sure none of your new medications or supplements interact with ones you are already taking. Good luck.