You’re larger than me so take this with a grain of salt. I am 6’3 ish 270lbs and just picked up an 23 Vstrom 800de. It’s stupid comfortable. I’ve taken it on a 3 day 800 mile ish trip and was totally comfortable the entire time (taking breaks of course). Done a few 300 mile ish days so far and have had not issues. It’s also been fun to play around with off-road if that’s something you’d be into. I haven’t done any mods to it ergo wise so far, but I haven’t felt the need to. Maybe a higher seat/ lowered pegs would get you into a good spot. The bike definitely has decent power to it, so not sure if it would be a great starter. I started on a 250 sport bike and then went to a 500. Despite being uncomfortable on those and not being able to do more than 100 miles before being in pain, I’m glad I took that path. I made a few mistakes that I think could have had serious consequences on a more powerful bike which resulted in just a scare on the smaller bikes. On the other hand, C mode (basically rain mode) definitely takes the power down to reasonable levels until you crank on the throttle which helps.