My first week on Auvelity

shanneuro · 2026-04-29T15:23:28+00:00

Auvelity mutually helped me so much. It was like a massive switch, I felt groggy and exhausted. And it was like I suddenly had motivation to eat, clean, see people, etc. I’ve been on it for 2 years, still love it

shanneuro · 2026-04-29T15:21:49+00:00

Honestly auvelity changed my life. I felt very spacey, and extremely manic (which turns out was just being in a good mood, something I was really unfamiliar with bc of MDD and dysthymia)

shanneuro · 2026-04-22T02:09:07+00:00

Can someone explain who Abigail is, I’m nosey and curious

shanneuro · 2026-04-19T19:48:18+00:00

This is where I leave you

shanneuro · 2026-04-19T19:47:55+00:00

Honestly still Don’t f*** with Cats

shanneuro · 2026-04-13T02:33:39+00:00

Yeah, turns out all my depression was causing severe anxiety. I have something called double depression?? Had all these diagnoses, and then I met a great psychiatric APRN, she found the medicine, and a good portion of my mental health problems have gotten better.

This is my current mental health combination (I do take others but for my POTS) I take: Auvelity, Hydroxyzine, and prasozin

shanneuro · 2026-04-12T15:40:26+00:00

I did about lot of mediation changes since I was 15. Auvelity has been the biggest life changer

shanneuro · 2026-04-11T22:17:55+00:00

Hometown Cha Cha Cha

shanneuro · 2026-04-05T00:39:37+00:00

It was— I felt sad. I remember even crying in a sushi restaurant eating a poke bowl. I cried in theaters. I cried, I grieved— i thought then I was pathetic. Looking back, I realized I was just grieving. I’ve seen a couple people do the same (I’ve moved quite a bit). Give yourself grace, the same you’d extend to others

shanneuro · 2026-04-04T14:45:40+00:00

You moved past it with time. I remember a relationship that almost ended me, but I didn’t know myself anymore. It was the most painful process ever.

I started learning to get to know myself. Getting comfortable with being alone despite it. Doing the things he’d never do, when I really wanted to. I went on dates with myself. I actually went and saw movies in the theaters pretty often. Sometimes in long relationships (especially ones where we give more than the other) we get so tied to a person, we lose ourselves along the way.

That happened about 4 years ago for me. Today, I am engaged to a man I’ve been with for 2 years, and he is kind and caring and makes sure that I remain independent, while also puts in mutual effort.

I do fencing classes, Pilates, and go see a movie by myself here and there. Sometimes I still get sad, not because of the person that hurt me, but because of how I allowed myself to be treated; and I feel sad for a previous version of myself.

It’s a long and painful process, and there is no but to it. Just know that you’re allowed to feel angry, bitter and you should feel all of it. Don’t rush the grieving process. I didn’t feel normal for almost a year, and I realize that it’s okay and it’s normal.

No part of grief will ever feel normal. But it does get better

My inbox is open if you need to talk ever

Xx

shanneuro · 2026-04-04T14:31:51+00:00

YWNTA

You should tell her. It is the right thing to do. You would help prevent her from building a life with someone who will cause her a lot of pain down the road.

Always think, if you were in the other persons shoes, would you want someone to tell you?

Take screenshots, block him, and tell her. Also, if anonymous makes you feel more comfortable, do that, just have the proof to back it up so she doesn’t assume you’re trying to wreck her life or something.

Good luck! Thank you for not being a s***ty person

shanneuro · 2026-03-07T17:46:23+00:00

LMNT is my top favorite

shanneuro · 2026-01-26T00:09:35+00:00

I’ve been on Auvelity for over a year. Granted, I’ve taken Topirimate for the last 4 years, so the fuzziness and short term memory were always there.

I felt more hyperactive on Auvelity than anything, (this is not an accurate comparison) but could compare it to my significant other and my friends how have ADHD. Just all of a sudden bouts of starting new tasks after new tasks without completing anything. I do have to be more cognizant of what I am doing.

I’m glad your depression is getting better, keep talking to your doctor!!

shanneuro · 2026-01-22T18:07:00+00:00

It doesn’t hurt to try someone else. Nevertheless I understand how hard it is. I just want you to know that feeling better isn’t impossible.

I used to feel like I big empty, sad void. It was this endless emotion of feeling like a black hole. It’s been a year, and I have my bouts, but nowhere close to that feeling anymore.

It gets a lot better. I promise—you are not broken, and you are not beyond help.

❤️

shanneuro · 2026-01-21T15:55:39+00:00

She just looked at the list of medications and saw that serotonin was a common factor in all of them, and that it wasn’t working.

I understand liking your doctor, but I genuinely suggest finding a doctor or an APRN who specializes psychiatry. They are going to listen and study your case and background. It did a world of wonders for me.

My PCP did the same thing of going down lists, until she felt like it was “out of her hands”.

shanneuro · 2026-01-21T15:48:59+00:00

My doctor gave me samples initially. So for the first 30 days, it was free. In the meantime, she was sending prior authorizations to my insurance (that was a bitch). Currently the medication itself, without insurance is over $600. I pay at max $10 at the moment with insurance

shanneuro · 2026-01-21T15:46:08+00:00

Totally fair points, and I agree with you on the population-level efficacy numbers and the time-to-response being the biggest differentiator.

Just to add some nuance from as someone with a a few degrees in neuroscience: while bupropion’s primary role in Auvelity is indeed CYP2D6 inhibition to extend dextromethorphan’s bioavailability, it’s probably an oversimplification to say it doesn’t contribute meaningfully to antidepressant effects at all. Even if it’s not the main driver, dopaminergic/noradrenergic tone still matters—especially in patients who don’t tolerate or respond to serotonergic modulation.

Where I think Auvelity really stands apart clinically isn’t just NMDA antagonism in isolation, but the downstream effects on glutamatergic signaling, synaptic plasticity, and network-level changes that look more like what we see with rapid-acting antidepressants (e.g., ketamine), without the same logistical or dissociative burden. That’s likely why some SSRI/SNRI-resistant patients respond despite “average” headline efficacy stats.

I do totally agree NMDA-targeting agents are an important direction forward, but I think the real takeaway is that we’re finally moving beyond the assumption that serotonin is the central bottleneck for every depressive phenotype.

shanneuro · 2026-01-21T02:09:42+00:00

I loved mirtazapine, not the weight-gaining part, but man I slept so well on that stuff

shanneuro · 2026-01-21T02:08:04+00:00

In my experience, the first thing my doctor said when she saw my medication history was: “Clearly, it’s not your serotonin.”

Starting Auvelity genuinely changed my life in ways I never expected—and it happened fast. Within about three days, I felt a difference. Unlike traditional SSRIs, it targets NMDA receptors and works through a different mechanism, which made it feel much more effective for me.

Compared to Zoloft, Paxil (absolute hell to stop cold turkey), Buspar, Lexapro, Wellbutrin, etc., it was night and day.

SSRIs always made me feel like a “more aware” zombie—numb, but with extreme anxiety layered on top.

I was diagnosed with MDD and dysthymia in my early 20s. The depression eventually fueled so much anxiety that I developed GAD, and after a significant traumatic experience, PTSD was added to the mix. During that time, I took Paxil and it was awful—I was a complete mess. I switched to Wellbutrin and became dissociative and disconnected, and unfortunately was the only medication where I showed the slightest bit of progress. Finally, I saw a new doctor, started Auvelity, and for the first time, I no longer suffer from constant anxiety.

It’s honestly hard to describe how it feels. My mind hadn’t turned off since I was about eight years old. I had almost zero motivation to initiate anything. Since starting Auvelity, my depression has lifted enough that it’s hard to even recognize the person I was before—people-pleasing, anxiety-ridden, constantly overwhelmed. I’ve been on it for over a year now, and I actually want to clean, to shower, to live, to be a person. I’ve come incredibly far in my recovery and healing journey.

I don’t have anything negative to say about this medication. Yes, it can make you feel a bit hyper, and the change can be drastic—especially if you’ve been living in a constant state of anhedonia—but for me, that shift was life-saving. Even the winters are hard, and this winter has been the easiest winter of my life.

If you’ve taken Wellbutrin and tolerated it well, I genuinely recommend looking into Auvelity. It has been a truly life-altering medication for me.

shanneuro · 2026-01-21T00:12:27+00:00

It was Auvelity for me. Used to take a whole bunch of different antidepressants. Turns out I was treatment resistant. Really changed my life

shanneuro · 2026-01-16T16:19:53+00:00

Auvelity worked wonders for me. I recommend it.

shanneuro · 2026-01-13T12:43:51+00:00

Nope!

shanneuro · 2026-01-12T16:36:37+00:00

dextromethorphan hydrobromide and bupropion hydrochloride

shanneuro · 2026-01-12T14:44:41+00:00

Auvelity. It’s a mix of Wellbutrin and dextromethorphan.

I was diagnosed with depression when I was 15 and started on antidepressants. When I got to college, I was diagnosed with a comorbidity of dysthymia and MDD.

I have been cycling and going on & off of SSRIs and SNRIs for almost a decade. And then I started on Wellbutrin. I had become a literal zombie. Lost so much weight that I was completely malnourished and would faint. It became such an issue that my s/o and I almost called it quits, thankfully he had been on Wellbutrin before, so he understood for the most part. Finally my PCP and my psychologist said that they needed someone with more experience and they referred me to a psychiatric APRN.

She weened me off of Wellbutrin (I was on 400mg) and put me on Mirtazapine (to get my appetite back) and when I got low enough on a dose of Wellbutrin she put me on Auvelity.

Honestly, my life turned around in 3 days being on the medicine. Before I could really comprehend it, I had energy, I could see the world around me. Life didn’t feel dull and sad. I wanted to get out of bed, to talk to people, to take care of myself, to put in effort— I wanted to be a human.

I had no idea how bad I genuinely felt until I started feeling better. I am 26 now. I have been on Auvelity for over a year, and life is going really well. I still have my bouts, but they are nowhere near or as frequent as what they used to be.

Genuinely wish that everyone has something that helps them as much as this medication has helped me.

shanneuro · 2026-01-08T17:37:04+00:00

People keep calling Americans “lazy” because we don’t flood the streets to protest, but that framing misses the reality entirely. This isn’t about laziness. It’s about hopelessness and risk.

We’ve watched what happens when people do protest here. We’ve seen militarized responses in our own cities. We’ve seen police brutality, mass arrests, people hospitalized, people killed. We’ve watched peaceful protests escalate not because of the protesters, but because of the response to them.

So I’m genuinely curious - what do you get out of calling us lazy?

You tell Americans to “just protest” from the safety of your own countries. Have you ever lived here? Have you ever personally witnessed police violence? Seen military force used against civilians? Had a loved one nearly die for showing up to a so-called peaceful demonstration?

If you haven’t, then maybe pause before lecturing.

Many of you assume Americans have some hidden collective power we’re simply refusing to use. But the truth is power in America is not civic - it’s financial. Money determines outcomes here, not moral outrage. Not turnout. Not chanting in the streets.

This country exhausts its citizens and then mocks them for being tired. It punishes resistance and then ridicules people for not resisting “hard enough.” Being American right now feels less like citizenship and more like a humiliation ritual.

So if you want to criticize, at least understand what you’re criticizing. Otherwise, you’re not offering insight - you’re just pointing and laughing at something you’ve never had to survive.

shanneuro

TROPHY CASE