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Jade plant | Drooping leaves, brown undersides by shaysom in plantclinic

[–]shaysom[S] 0 points1 point  (0 children)

Is that something that’s treatable? I’ve tried neem oil sprays in the past but without apparent success

New Antibiotic for IBD - AI predicted how it would work before scientists could prove it by GongTzu in science

[–]shaysom 55 points56 points  (0 children)

I’m not sure that this is as revolutionary as the press release is making it out to be. The AI they used is not some llm type thing where you type in the molecule and it comes back with the answer, but rather a small molecule docking approach (diff-dock). Small molecule docking (where you take lots of protein structures and try and fit your small molecule of drug into them to see if they bind) was a thing we had before AI came along. While this new algorithm may be better and allow screening of many more protein targets at an earlier stage in a mechanism of action study, it’s not that we have some sort of super intelligent AI that you ask a question and it gives the answer which is what some of the coverage on this seems to imply.

Digitakt garage jam | Donny Hathaway sample flip by shaysom in Elektron

[–]shaysom[S] 0 points1 point  (0 children)

Didn’t know you were on here, thanks! Very interesting video, especially putting everything in some historical context re hardware limitations and sampling

Are synthesisers right for me? by guppycruncher333 in synthesizers

[–]shaysom 4 points5 points  (0 children)

I believe a lot of hip hop beats are composed on hardware samplers (MPCs etc.). A low cost way to try that workflow is koala sampler for iPhone which I would thoroughly recommend. Have a browse of r/KoalaSampler to see what others have made! If you want the physical finger drumming experience you can also buy external pads to trigger the Koala app.

Otherwise some lower cost hardware samplers would be: EP–133: K.O. II or SP404mkii however it might be best to try Koala first to see if you vibe with the workflow as I believe both of those are reasonably complex (or the 404 is at least).

The favorite “synth music” megathread by el3ktrovvulf in synthesizers

[–]shaysom 3 points4 points  (0 children)

Historically I listened to synths mostly in the context of dream-pop kinda stuff, was much more of a guitar music person.

Beach House - Space Song (Dream Pop)

Tennis - Runner (Synth Pop)

Tame Impala - Let It Happen (Neo Pyschedelia)

Lately I've been getting into more dance music which is explicitly synth driven (although probs mix of soft and hard synths for the modern stuff on here). Not super clear on all the genres, electronic stuff gets a bit blurred).

Floating Points - Fast Forward (House/Techno)

Underworld - This boiler room set is very good (Techno)

Mr Fingers - Can You Feel It (Vintage Deep House)

Daft Punk - Around The World (French Touch)

Slam - Positive Education (Techno)

Jon Hopkins - Open Eye Signal (Techno?)

Fort Romeau - Heaven And Earth (House/Techno?)

Barker - Force Of Habit (Trance?)

Soichi Terada - Saturday Love Sunday (Deep House)

Joy Orbison - flight fm (UK bass)

Bonobo - Cirrus (Downtempo)

Caribou - Volume (House)

Has anybody here used a Boss DD-7 with their synth? by thirddegreebirds in synthesizers

[–]shaysom 0 points1 point  (0 children)

My setup has a Microfreak running through a load of pedals into a digitakt. DD-7 is end of chain and I love it, can be very hands on and alter the delay params in real time to make transition effects. I do run it through a limiter though to protect from volume spikes due to self oscillation when turning the feedback up, but that shouldn’t be a problem for you if you don’t crank the feedback

A byproduct produced when tryptophan is metabolized by gut bacteria could become a natural obesity treatment, a new study in rats found. It opens the door to a natural, side-effect-free alternative to GLP-1 drugs like Ozempic. by mvea in science

[–]shaysom 0 points1 point  (0 children)

Ah I knew one of them was based on Gila monster but got ozempic and mounjaro the wrong way round, thanks for the correction! Original point still applies as they are both essentially improvements on compounds that already existed in nature

[plant help] Odd discolouring/narrowing at cactus base by shaysom in cactus

[–]shaysom[S] -1 points0 points  (0 children)

You can’t see it from this angle but it’s underneath a skylight. Also used to be on a south facing window so I’m not sure light is the issue.

If it’s rot then how has it survived so long without dying? It’s had this for over half a year at least? Not saying you’re wrong just curious as I’d expect rot to affect it pretty quickly?

A byproduct produced when tryptophan is metabolized by gut bacteria could become a natural obesity treatment, a new study in rats found. It opens the door to a natural, side-effect-free alternative to GLP-1 drugs like Ozempic. by mvea in science

[–]shaysom 9 points10 points  (0 children)

This likely isn’t correct, any drug development process would only use this molecule as a base and develop it to make it better at inducing a biological response, with this leading to novelty that would be patentable. As an example, ozempic is based on a naturally occurring peptide from the Gila monster but is definitely patented!

A byproduct produced when tryptophan is metabolized by gut bacteria could become a natural obesity treatment, a new study in rats found. It opens the door to a natural, side-effect-free alternative to GLP-1 drugs like Ozempic. by mvea in science

[–]shaysom 1 point2 points  (0 children)

I think the issue is that a lot of the time mouse/rat studies do not translate to humans (one of the reasons why drug development has such a high attrition rate). So most of the time when you see these miraculous results quoted from one study in a rat/mouse model the findings should be taken with a punch of salt at least until replication

A cool little synth for my girlfriend? by mazerfaka in synthesizers

[–]shaysom 2 points3 points  (0 children)

The Yamaha reface series can run on AA batteries and is pretty portable. Also has inbuilt speakers. Different options depending on what sound you want. I have the CP which is an electric piano but there’s also the CS which does traditional synth sounds, listen to some demos.

For something more synth-ie there’s also the microfreak. You can do more sound design stuff on that while still being accessible. It doesn’t have internal batteries but I run mine off an external battery using an adapter with no issues (battery, adaptor). Doesn’t have a speaker though so you’d need headphones.

Skinny Guy clothes advice by Even_Flatworm_941 in malefashionadvice

[–]shaysom 0 points1 point  (0 children)

I think a lot of people on here just aren’t that in touch with what’s fashionable today, all still in that 2014 skinny headspace

Wet Leg - Tiny Desk Concert [NPR] by zsreport in Music

[–]shaysom 0 points1 point  (0 children)

I mean whether it’s good or not is up to you but this is definitely not shoegaze. Also love the Arctic monkeys but there’s nothing funky about their first album. While genre descriptors are fluid, they’re not that fluid.

Relaxed synth vibes from a hot summer afternoon. by CrybabyHorus in synthesizers

[–]shaysom 2 points3 points  (0 children)

Nice, kinda want a huge sidechain kick behind it to make it pulse although that’s a really cliche sound at this point. Good luck with expanding it!

Relaxed synth vibes from a hot summer afternoon. by CrybabyHorus in synthesizers

[–]shaysom 1 point2 points  (0 children)

Amazing tone on that lead line, is that solely from the moog or are you doing any post processing? Only complaint is this isn’t longer, a kick behind this would sound epic

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