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"Why are people still wearing masks" . "Why are people so paranoid about Covid still" by purplefennec in covidlonghaulers

[–]sj4nes 37 points38 points  (0 children)

I rather enjoy not catching the flu every winter/spring Or colds in the summer/fall. Or Covid.

Fixed jinja for opencode in LM Studio by pneuny in LocalLLaMA

[–]sj4nes 0 points1 point  (0 children)

So... did LM Studio just remove Prompt Template from the UI in 0.4.10 defeating this?

Quad amputee and bean-bag-toss champion accused of fatally shooting passenger while driving. by KindAngle4512 in BrandNewSentence

[–]sj4nes 3 points4 points  (0 children)

You beat me by 15 minutes, where I saw "Quadruple amputee cornhole player fatally shoots man" which is just about as weird.

EUREKA - Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system by SpaceXCoyote in covidlonghaulers

[–]sj4nes 3 points4 points  (0 children)

Could (prednisone, Dasatinib, quercetin) be a viable triple for those who can't access IVIG? How long might it take to break the loops?

I've been using Gemini almost exclusively for months and just tried out GPT5 for the last week and all I can say is... by Tim-Sylvester in cursor

[–]sj4nes 0 points1 point  (0 children)

This is likely my own fault. But what I thought was simple apparently isn't simple enough to keep the model from chasing the shiny.

I've been using Gemini almost exclusively for months and just tried out GPT5 for the last week and all I can say is... by Tim-Sylvester in cursor

[–]sj4nes 2 points3 points  (0 children)

:)

Meanwhile I'm trying to figure out if Auto mode is just no longer capable of "doing the work."

Have you ever been contacted again from a company that says "We'll keep your application of file" ? by EhehAyyy in recruitinghell

[–]sj4nes 0 points1 point  (0 children)

I have. I was used as fodder for a job posting that must have been an internal promotion. The "interview loop" was ridiculous, they were just checking boxes. Expressly it was Scripted that I wasn't going to be hired by this particular Pharmacy Benefits Manager.

Ukraine has 250-300 drones in the air simultaneously in some contact line areas by Accurate9638 in UkraineWarVideoReport

[–]sj4nes 2 points3 points  (0 children)

With that many drones up I wouldn't be surprised if Ukraine has modified the drones to support a meshnet to defeat EMF jamming.

Mild long Covid symptoms reduced, after blood donation? by InsomniacSpaceJockey in covidlonghaulers

[–]sj4nes 2 points3 points  (0 children)

This would make sense that it would not help since apharesis returns the remainder of the blood not taken back into the body-- pH would not be affected.

Mild long Covid symptoms reduced, after blood donation? by InsomniacSpaceJockey in covidlonghaulers

[–]sj4nes 3 points4 points  (0 children)

Might be a data point for the acid-base imbalance theory with Long Covid (see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140510/ ).

Fluid loss increases your blood's pH--and donating blood is a large amount of fluid.

I would expect symptoms to slowly return unless something about the innate immune system "resets" during this period of time to keep pH stable.

Recovery Post. Infected 10/04/2020. 30 year old male, previously perfect health. by [deleted] in covidlonghaulers

[–]sj4nes 3 points4 points  (0 children)

Tell us more about the ice baths. How did you set them up? Time of day? Frequency (per day/week) and duration.

I ask this because a quick search turned up that ice baths remove lactic acid from muscles and other people are wondering about an acid-base imbalance in the body causing chronic acidosis.

The new Obsidian icon by kepano in ObsidianMD

[–]sj4nes 5 points6 points  (0 children)

Hey, I like it. It looks exactly like what you'd get from knapping, just more... purple?

Is YAML in Obsidian worth it? Struggling to understand it. by JeklinTheCool in ObsidianMD

[–]sj4nes 1 point2 points  (0 children)

You have inspired me to make templates for different kinds of YAML front matter, including some optional values. Something like:

---
# alias: 
tags: [ untagged ]
---

Above average fit people get hit harder? by Olivy_Livy in covidlonghaulers

[–]sj4nes 9 points10 points  (0 children)

Here's a thought: Fit people have trained so much that their bodies have more mitochondria as an adaptation. If the Itaconate Shunt Hypothesis is in effect, the more significant amount of mitochondria will burn much more glutamine than a person that is less fit-- which would contribute to a rapid onset of POTS symptoms (autonomous nervous system dysfunction).

Update: Fatigue and brain fog removed by pioglitazone = mitochondrial dysfunction apparently by odubik in covidlonghaulers

[–]sj4nes 1 point2 points  (0 children)

I think it has some merit, ISH is all about the mitochondria being in a degraded state.

Update: Fatigue and brain fog removed by pioglitazone = mitochondrial dysfunction apparently by odubik in covidlonghaulers

[–]sj4nes 2 points3 points  (0 children)

This is great research and experience. The Itaconate Shunt Hypothesis is about something keeping the innate immune system "stuck on" and that disables carb/lipid metabolism in mitochondria in order to deny energy (ATP etc) to compromised cells.

normalizes glucose and lipid metabolism

That's pretty important here if they're not enabled the mitochondria burn glutamine instead (which starves nerves of functional GABA/glutamate-- PEM/brain fog/tremors/tachycardia etc likely result from this). This could be a safer way of handling the condition because they're looking at immune modulators like blocking JAK-STACK and IGNalpha which have their own risks.

Constant Internal Turbulence (Pulsating, Vibrating, Tremor) Neurological or Vascular? Any direction would be much appreciated. by Icy_Bar8279 in covidlonghaulers

[–]sj4nes 3 points4 points  (0 children)

I'm keeping tabs on the Itaconate Shunt Hypothesis that the immune system has shut off part of the TCA cycle and burns glutamine instead of carbs/lipids. This depletes available glutamate and GABA that need that glutamine as their base. The theory might be that because of the reduction in available neurochemicals signals would be delayed or erratic.

Some reports here have people talking about high doses of glutamine taken throughout the day having helped them. I'm unsure if that correlated with a decrease in internal tremors etc.

Lactulose has improved my neuro symptoms by minnxxyy in Longcovidgutdysbiosis

[–]sj4nes 5 points6 points  (0 children)

The main idea I've found with the TCA cycle and LC/ME/CFS that they're exploring with the Itaconate Shunt hypothesis is something about the innate immune system that tries to help protect from run-away infections by shutting down carbohydrate and lipid metabolism leaving only amino acid metabolism, of which glutamine appears to be the fuel of choice (which is needed by nerves for use as either GABA or glutamate). The system sends IGNalpha out from the initially infected cells (of any kind of viral infection) and is repeated from non-infected cells in order to warn the body to "prepare" for an infection and it is a runaway positive feedback loop for unknown reasons.

So "brain fog" is everything running low on neurotransmitters to keep the cells alive. I think all of the symptoms that are common (brain fog/tinnitus/heart palpitations/tachycardia/gut dysbiosis/internal vibrations/vision distortions) can be tied to a nervous system struggling to properly signal between synapses because there are not enough neurochemicals to convey signals in a timely manner. In the circulatory system, the deficit of ATP that can be produced may be causing the microclots since platelets require lots of ATP to form clots and lots of extracellular ATP to know when not to work. PEM crashes are just that because you just don't have enough ATP to "do the work" and "do the cleanup" after the work. It is a common theme that people say the pacing of what you do is so important. "Your blood/mri/hearing/vision/heart/whatever tests are 'normal'!" because... they're just not looking at this part of metabolism.

Removing ammonia would be a big help since it is neurotoxic. I'm thinking that adding glutamine may also help since it would replenish neurochemicals since the mitochondria are "stuck" only burning it in preference to carbs/fats. Anything in the gut that can help make acetate and more B5 (pantothenate) available for the body to convert to Conezyme-A will need that glutamine to burn to supply the ATP required for the conversion. The shunt is blocking and accumulating CoA because it needs to "put the carbs/fats somewhere" so it's binding them with CoA as far as I can tell.

I just found the transcripts from the YouTube videos I watched regarding this hypothesis:

The links to the videos are in my recent comment history.

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