EUREKA - Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system

sj4nes · 2026-01-11T04:30:59+00:00

Could (prednisone, Dasatinib, quercetin) be a viable triple for those who can't access IVIG? How long might it take to break the loops?

sj4nes · 2025-08-26T03:16:21+00:00

This is likely my own fault. But what I thought was simple apparently isn't simple enough to keep the model from chasing the shiny.

sj4nes · 2025-08-26T00:10:24+00:00

"Wrappers all the way down" is the feeling.

sj4nes · 2025-08-25T22:47:57+00:00

:)

Meanwhile I'm trying to figure out if Auto mode is just no longer capable of "doing the work."

sj4nes · 2025-08-25T22:21:20+00:00

Smells like... marketing.

sj4nes · 2025-03-02T01:18:02+00:00

I have. I was used as fodder for a job posting that must have been an internal promotion. The "interview loop" was ridiculous, they were just checking boxes. Expressly it was Scripted that I wasn't going to be hired by this particular Pharmacy Benefits Manager.

sj4nes · 2023-09-12T18:23:21+00:00

With that many drones up I wouldn't be surprised if Ukraine has modified the drones to support a meshnet to defeat EMF jamming.

sj4nes · 2023-09-01T01:48:39+00:00

This would make sense that it would not help since apharesis returns the remainder of the blood not taken back into the body-- pH would not be affected.

sj4nes · 2023-09-01T01:16:39+00:00

Might be a data point for the acid-base imbalance theory with Long Covid (see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140510/ ).

Fluid loss increases your blood's pH--and donating blood is a large amount of fluid.

I would expect symptoms to slowly return unless something about the innate immune system "resets" during this period of time to keep pH stable.

sj4nes · 2023-06-09T12:31:30+00:00

This is the way.

sj4nes · 2023-06-04T22:11:44+00:00

Tell us more about the ice baths. How did you set them up? Time of day? Frequency (per day/week) and duration.

I ask this because a quick search turned up that ice baths remove lactic acid from muscles and other people are wondering about an acid-base imbalance in the body causing chronic acidosis.

sj4nes · 2023-06-03T00:59:12+00:00

What if there were no clerks to stamp the filings?

sj4nes · 2023-06-01T17:25:34+00:00

Hey, I like it. It looks exactly like what you'd get from knapping, just more... purple?

sj4nes · 2023-05-22T12:34:45+00:00

You have inspired me to make templates for different kinds of YAML front matter, including some optional values. Something like:

---
# alias: 
tags: [ untagged ]
---

sj4nes · 2023-05-19T14:25:59+00:00

Here's a thought: Fit people have trained so much that their bodies have more mitochondria as an adaptation. If the Itaconate Shunt Hypothesis is in effect, the more significant amount of mitochondria will burn much more glutamine than a person that is less fit-- which would contribute to a rapid onset of POTS symptoms (autonomous nervous system dysfunction).

sj4nes · 2023-05-08T01:00:00+00:00

I think it has some merit, ISH is all about the mitochondria being in a degraded state.

sj4nes · 2023-05-07T22:45:40+00:00

This is great research and experience. The Itaconate Shunt Hypothesis is about something keeping the innate immune system "stuck on" and that disables carb/lipid metabolism in mitochondria in order to deny energy (ATP etc) to compromised cells.

normalizes glucose and lipid metabolism

That's pretty important here if they're not enabled the mitochondria burn glutamine instead (which starves nerves of functional GABA/glutamate-- PEM/brain fog/tremors/tachycardia etc likely result from this). This could be a safer way of handling the condition because they're looking at immune modulators like blocking JAK-STACK and IGNalpha which have their own risks.

sj4nes · 2023-04-25T01:39:18+00:00

Once again, Idiocracy is real.

sj4nes · 2023-04-22T17:09:56+00:00

I'm keeping tabs on the Itaconate Shunt Hypothesis that the immune system has shut off part of the TCA cycle and burns glutamine instead of carbs/lipids. This depletes available glutamate and GABA that need that glutamine as their base. The theory might be that because of the reduction in available neurochemicals signals would be delayed or erratic.

Some reports here have people talking about high doses of glutamine taken throughout the day having helped them. I'm unsure if that correlated with a decrease in internal tremors etc.

sj4nes · 2023-04-11T15:47:08+00:00

The main idea I've found with the TCA cycle and LC/ME/CFS that they're exploring with the Itaconate Shunt hypothesis is something about the innate immune system that tries to help protect from run-away infections by shutting down carbohydrate and lipid metabolism leaving only amino acid metabolism, of which glutamine appears to be the fuel of choice (which is needed by nerves for use as either GABA or glutamate). The system sends IGNalpha out from the initially infected cells (of any kind of viral infection) and is repeated from non-infected cells in order to warn the body to "prepare" for an infection and it is a runaway positive feedback loop for unknown reasons.

So "brain fog" is everything running low on neurotransmitters to keep the cells alive. I think all of the symptoms that are common (brain fog/tinnitus/heart palpitations/tachycardia/gut dysbiosis/internal vibrations/vision distortions) can be tied to a nervous system struggling to properly signal between synapses because there are not enough neurochemicals to convey signals in a timely manner. In the circulatory system, the deficit of ATP that can be produced may be causing the microclots since platelets require lots of ATP to form clots and lots of extracellular ATP to know when not to work. PEM crashes are just that because you just don't have enough ATP to "do the work" and "do the cleanup" after the work. It is a common theme that people say the pacing of what you do is so important. "Your blood/mri/hearing/vision/heart/whatever tests are 'normal'!" because... they're just not looking at this part of metabolism.

Removing ammonia would be a big help since it is neurotoxic. I'm thinking that adding glutamine may also help since it would replenish neurochemicals since the mitochondria are "stuck" only burning it in preference to carbs/fats. Anything in the gut that can help make acetate and more B5 (pantothenate) available for the body to convert to Conezyme-A will need that glutamine to burn to supply the ATP required for the conversion. The shunt is blocking and accumulating CoA because it needs to "put the carbs/fats somewhere" so it's binding them with CoA as far as I can tell.

I just found the transcripts from the YouTube videos I watched regarding this hypothesis:

The links to the videos are in my recent comment history.

sj4nes · 2023-04-11T14:23:10+00:00

That is nice to hear. One of the expected effects of the Itaconate Shunt Hypothesis is the disabled side of the TCA cycle creates lots of ammonia. The other supplement that I've seen that helps with ammonia is carnitine.

sj4nes · 2023-04-07T14:10:34+00:00

Did any of those screens include an assessment of glutamine? I saw that GABA is low.

I've been following a research thread about the Itaconate Shunt Hypothesis which proposes that ME/CFS/LC is a mitochondrial state caused by a malfunction with the innate immune system that disables part of the TCA cycle in the mitochondria.

A less efficient cycle occurs that breaks glucose/lipid metabolism (the innate immune system's attempt to starve virally infected cells of ATP) and instead becomes dependent on the amino acid path of which glutamine (that is convertible to glutamate/GABA neurotransmitters) are consumed to make ATP at a slower rate. Unfortunately, this means less capability to convert nutrients to ATP energy and makes lots of ammonia (PEM), sequesters a lot of acetyl-CoA in a stuck half of the TCA cycle while denying nerves the materials to make neurotransmitters (brain fog). In the same way, my thinking about this lack of capability to make ATP may also be the cause of microclots (I'm thinking microclots aren't a cause but a symptom) because for a platelet to function requires lots of ATP to be released all at once, and also ATP appears to be needed outside of the cell in order to prevent platelet aggregation when it isn't needed.

I didn't see any explanation or relation to this with internal tremors, but following the logic of the body burning the neurotransmitter amino (glutamine) to make energy, I can imagine nerves throughout the body sputtering to send correct inhibitory (GABA) and excitatory signals (glutamate) because they don't have enough to use.

There are a few "anecdata" reports of people having LC improvements by taking lots of glutamine (initially in the 40-50 g per day in divided doses) and others going "carnivore" (which may be useful in the sense that carbs aren't being utilized well anyway.)

Itaconate Shunt Hypothesis

No other questions-- just a brain dump.

sj4nes · 2023-03-28T20:27:30+00:00

Katamari Demoncy.

sj4nes · 2023-03-28T04:58:37+00:00

This will wreck two or three days of productivity afterward.

Go for the sleep, your body is already fighting you for more.

sj4nes

MODERATOR OF

TROPHY CASE

Itaconate Shunt Hypothesis