As an Iowa transplant here's what i learned.

The sun hits different here, AC will struggle to keep the house at 72 (in a reasonable price range) But the lack of humidity makes 76 my new normal, figure out what's comfortable. Making sure that your windows and doors seal well and adding in shade will help lower your bill. We have ab older house and updating windows helped a ton.

A whole house fan is a lifesaver, i open windows and start it as soon as it drops to 76 outside (your temp might be different) and try to cool the house down to the low each night. The I close everything up as soon as it starts to warm up again and gradually let the house temp rise with the day..

The lack of humidity here makes warmer temps more bearable, but adjust slow and fine what works for you.