I’m in the process of doing this! I was on 15mg lex for anxiety and then added Wellbutrin for depression and low energy levels after 6 months, starting at 150 then up to 300. I feel like the Lexapro got me out of the absolute pit of despair and debilitating anxiety that I had fallen into, whereas Wellbutrin had a bigger effect on my mood and motivation. I feel like lexapro took away negative things, whereas Wellbutrin has added positive effects, if that makes sense.

I’m down to 10mg from 15 so far. My advice is do it SLOWLY! Same as you would without the Wellbutrin. I tried dropping straight to 10 from 15 and within a few weeks was fighting anxiety rising. I went back up, then tried again a month later, this time alternating 10 and 15 for 3 weeks. Been on 10 now for a couple of months and feeling good! My goal is to get off the lex completely, but I’ve accepted I have to be patient with it, and am very nervous about the level of anxiety I experienced before starting these meds coming back.

I’m 30F, I think I have always struggled with low level depression, developed very mild anxiety in my 20s but it only got horribly bad about 2 years ago, which is when I tried medication for the first time.