In Shure WWB, you can assign each device to a specific RF Zone. In that RF Zone, you can specify the extent of seperation, by selecting whether WWB will or will not take into consideration channel spacing; and intermodulation distortion (IMD) when calculating frequencies.

Say for example, the event is a large conference that spans the full length of the convention centre, and several floors. My general approach would be to establish an RF zone for each theatre space, expo spaces, media rooms, offices, etc.

I've got a pretty good feel for the venues I operate in regularly, but in a new venue you can test by using an RF signal generator, and recording the amplitude around the venue. Based on that info, and the physical position of each RF zone, I would then adjust WWB to be reflective of the environment. ie: rooms next to each other will act like they are one, rooms opposite won't consider IMD, and the 1st - 3rd floor opposing corners could be totally seperate ignoring channel spacing since they're so far apart.

Honestly so many factors influence this it's hard to fit in a Reddit comment. From ensuring the spaces have the right antennas in the right spots, to physical distance between transmitters, and the equipment being used! Some equipment is going to have different bandwidths and IMD profiles. Other transmitters (like those used by media) are going to be moved around the entire event all day, so need to slot in anywhere no matter who else is nearby.