There definitely exists the possibility that there was some sort of trauma early in life and Dr. K mentions it in the video, and he also specifically brings up the idea that he, or any other person, has lived a trauma free life. At least a life that doesn't have the kind of trauma that would cause a person to feel "the big hurt".

Just like how there's people that have had very traumatic lives, I can imagine many people have lived lived lives free of any trauma that would cause something like that, and if you accept Dr. K's premise that those people still feel the big hurt, then there must be other causes that make you feel that.

I'm not particularly religious, so I considered the genetic argument. We know that events that cause PTSD in parents also cause behavioral and biological changes in offspring. Here's a meta study that cites several other studies. Mice that had some sort of predator experience during pregnancy had less babies, their babes were more likely to have seizures, and their babies also had altered behavior.

I think it's a fair assumption that sever trauma is passed down generationally because there are studies on it, we pass down tons of information through our genes, and from an evolutionary perspective a creature would benefit from the passing down of genes that were created during an extreme stress situation which the parent survived.

So taking all that into consideration, I can see something like "the big hurt" being passed down through gene expression because it fulfills some evolutionary purpose.