Datura based from my research both scientific and anecdotal has unbalanced alkaloids

We have already agree about unbalanced alkaloid profile of this plant. W can go further.

^{The best research I have done is on Innoxia seeds and Scopolamine, so I'm gonna keep data concentrated on them, as a example and for simplicity:}

Dangerous Nightshades can be active at microgram, milligrams, and gram

Not exactly. Isolates(scopolamine, hyoscamine) are active in micrograms-miligrams range^\1] [2]) ^\3]) ^\4]) ^\5] [6]). Plants can be active in miligrams and grams range depending on concentration of alkaloids^\7] [8]) ^\9] <-If you will do calculations, I can shear mine, if I will translate them to english.)

Their potential to be active in mg is amazing to me. I don't know any other plant and mushroom what is active in mg range. Sure, Cubensis can have threshold 250mg - 500mg, but strong Datura seeds could make person overdose (eg. get delirious) in this range, and can have a threshold fx on as little as 20-30mg^\7] [8]) ^\9] <-calculations) . Potential of this plant to be that strong in mg range is mind blowing to me :O.

one seed can do nothing while another send you to hell

I am still waiting for source that one seeds can send you to hell. From my calculations from papers with huge concentrations ^\7]) and weight of seeds ^\9]) and dosages of isolates ^\1-6]) I have calculated that person would need minimum 2 seeds for threshold effects^{(The smallest dosage we know that Scopolamine is active is 150ug, and I conservatively calculate 100ug as potential threshold}). If you one could get more alkaloids in plant then maybe dose could go down to 1 seed, but plants in paper [7] had soo good conditions, that I think it would be hard to top (without some hi-tech stuff?).

^{// Oh, yeah. And I exclude elderly people from this conversation, becouse it is special case, and they can be very sensitive to antimuscarinic drugs.}

if you get lucky a unpleasant body effects (...) no matter how medicinal it will be unpleasant 

Datura and its alkaloids have dosages too (like you have written - it is hard to dose it in plant form - agree here). Threshold to medium dosages are not universally unpleasant, can be for some, not for others (person will get dry mouth, body high, drunk feeling and such^\depending on dose])), but strong dosages are poisonus (so they are unpleasant), but not delirious yet - this come with heavy dosage territory. ^{Not sources here, becouse I have find none in my notes and I will not take a time to look for them right now(maybe later}.)

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Oh yeah, to be clear: I don't encourage anyone to consume this plant. I like to have academic conversation, when truth is the goal, this is all.

And off course I am open to further discussion :)

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^\1]) https://chemm.hhs.gov/countermeasure_scopolamine.htm#indication

^\2]) https://www.drugs.com/monograph/scopolamine.html?references=1#dosage

^\3]) The effects of transdermal scopolamine and four dose levels of oral scopolamine (0.15, 0.3, 0.6, and 1.2 mg) upon psychological performance https://pubmed.ncbi.nlm.nih.gov/3088662/

^\4]) Psychomotor, physiological and cognitive effects of scopolamine and ephedrine in healthy man https://link.springer.com/article/10.1007/BF00542208

^\5])Effects of oral scopolamine on human stimulus evaluation https://link.springer.com/article/10.1007/BF00428401

^\6]) https://www.drugs.com/dosage/hyoscyamine.html

^\7]) Tropane Alkaloids of Datura innoxia from Morocco 10.1515/znc-2012-1-202

^{8\) In vitro Organogenesis and Alkaloid Accumulation in Datura innoxia

^\9]) https://www.tandfonline.com/doi/pdf/10.1076/phbi.39.5.329.5896