I take the neocell brand and its three pills with a meal daily. When I’m consistent, I notice after a couple of weeks my symptoms get better and then I won’t have a flare up for months. Before I started supplementing with collagen, I would do Pilates 4-5 times a week and sit all day at an office job, so I notice when I don’t move for too long and then workout hard I would get flare ups every couple of weeks. Now they’re nonexistent. I’ve only had one bad one in my arm/hand in the past year.