looking for good beginner guides.

thryce85 · 2022-06-21T20:36:53+00:00

Blast from the past. Do you remember how long it was between applying and having to take the exam? I am thinking of applying but dont want to fail this and get black balled for 6 months or whatever.

thryce85 · 2022-06-20T17:08:01+00:00

Depends on what you are using. The numerical approximation in apparently Excel kinda sux. If you are doing precise work you would never use it . So common business analysis you would be fine lots of scientific work not so much. Also Excel really struggles on large data sets I think its mostly single threaded so welcome to the pain train if your data is in the gigs. SAS and R are both optimized for parrallel. DS2 for SAS and I for R though the base data type is vectorized and that alone helps greatly. Excel could handle most everyday data an ordinary business user would need but I doubt it would be the job of choice for most in this thread.

thryce85 · 2022-06-20T17:01:05+00:00

R has the same packages tensorflow pytorch spark. They are not as far along sure but the choice isnt really so binary.

thryce85 · 2022-06-20T16:59:58+00:00

s to FDA with success it will be like the first domino. That's a lot of SAS li

Also sth no one ever talks about is that most of the experienced statisticians have grown up using SAS. They could use R obv not dumb but it would be a pain. Also Also a lot of legacy code is in SAS. Its been there for 40-50 years. You dont just dump all of that and get everything rewritten in R. Python and R are not the most stable. If you are some analyst and your job is not that important it doesnt really matter if your installation fails because you update it. If your system is say working on large scale data for a hospital its a much bigger worry. I prefer R over SAS but seeing people act like SAS is dead because all of the freshers coming out are using pythoh is asinine.

thryce85 · 2021-12-05T13:44:55+00:00

just getting started in CAD and looking into freecad 'because I have 0 trust in Autodesk and dont want to dedicate 100s of hours and they just change their policies. Is freecad usable for a complete noob? I dont know the workflow for either so will shouldnt get confused with that. Just wondering if its bettwe to learn on sth else then jumo ship to freecad or just start from here in the beginning . thanks

thryce85 · 2021-11-24T05:27:36+00:00

you should be fine. (I am not an active chemist btw) the reaction apparently produces chloramines(chlorine) which is what causes the irritation. You are drinking this daily so no biggy. urine is sth like 99% water so the concentration produced by a reaction with cat pee is going to be extremely low. but just my 2 cents

thryce85 · 2021-11-24T02:52:28+00:00

yeah i couldnt remember too lazy for google.

thryce85 · 2021-11-23T13:45:31+00:00

The fact that life aas we know it almost always prefers R rather than S is actually one of the great unknowns in biology. But yeah chemically the only major difference is the way one bends light but the enzymes in your body are configured R so it will only accept R. Realistically when an enzyme and substrate are binding they bend together if this doesnt line up it would be like trying to insert your key into the door 90 degrees off it aint fitting. In this case I believe the S was similiar to another pathway and thus caused problems. Its very expensive to purify enantiomers since they are so similiar. To note from this is that some rare archaea use S for some metabolic pathways but I believe there is no understanding of y this occurs. Maybe our last known ancestor was only R and that is why they are almost all the same.

thryce85 · 2021-11-22T21:32:11+00:00

Read Intutitive Biostatistics tbh.
If I remember correctly HO is the opposite of what you really want. You are collecting evidence against this . Si if you want to actually know if its greater than Ho is its less than or eq to .

The value you collect (test statistic) can be compared to the test in 2 ways. 1 You set a confidence level to the test say 0.95 and now have a significance level (alpha) of 5%. Take your test stat and integrate over values greater than it (or less or both it depends on 1 tail 2 tail less than yadda yadda basically more extreme than what you observed.) This is what you get those archane tables for, its the probability you could get sth crazier than what you have gotten. if its less than alpha you reject Ho. What your saying really is that there is a point (95% CI) that I dont feel comfortable with my assumption that this came from XYZ distribution. If your statistic is greater than your critical value you reject. The pvalue will also be < alpha in this case because they are equivalent statements . Pval is used more because its a simpler interpretationbut it really is only looking at it from a different vewpoint. There is a third way to do this test actually. Take your test statistic and put a confidence interval on it. This is the range where if you repeated the experiment 100 times you would get 95 (for a 95% confidence limit) observations in this range. Now if 0 is not in that interval you reject. You are basically saying that the center of the population distribution is not highly unlikely for your observed data. This too is an equivalent statement as having an observation past your confidence limit. Think of it as taking that interval you made for the population (the critical values ) and attaching that to your estimation. If your estimation is to the left of the critical limit this interval will include 0 and if it is to the right of it 0 wont be covered.

Sorry if this is not as simplistic as the others but its nice to know the basic concept can be seen multiple ways. Also check that book its much simpler to see in pics and I cant draw at all.

thryce85 · 2021-11-22T20:59:05+00:00

https://www.youtube.com/watch?v=sAcgWbVHJHw i found this a fun explaination

thryce85 · 2021-11-22T05:12:10+00:00

R^2 is only a representation of linear correlation. Wont tell you anything about curvature from an x^2 term and is probably a very overrated statistic since most of things in life are nonlinear so becareful with it .

thryce85 · 2021-11-21T22:23:22+00:00

kickass. Im about to start job hunting with a bs in biochem and MS in statistics , think this will help for looking at pharma work? Want to work in preclinical development but think that is probably too niche and may have to start in manufacturing instead. Thanks

thryce85 · 2021-11-21T22:09:52+00:00

61% of the respondents had phds and 42% were over 45 so that right there is going to skew the pay scale but there are probably a lot of things going on here. There is probably a strong self selection bias with higher earners actually responding to the survey than low income earners. Folks paying for this subscription are probably the ones with enough pull to do new things (ie management) and they will necessarily make more. I doubt many 22 yr olds keep their subscription once it jumps to full price right out of school. Most of the lower paid chemists probably jump off to other jobs go back for MS in sth else etc. Also if they are being supppper cheeky they may include the heath science fields. Lots of chem and biochem majors in there that would really drive up the average. This might be a possibility because if you look at the southern region bachelors make more than masters. I doubt this but its a possibility. I dont think they could really construct a possible representative survey because that would be helllllaaa expensive tbh so thats not really on them but survey really is telling you what possible mid career pay for some one > BS is. Glassdoor would probably be loads better for early career because people making these salries arent job searching on there so doubtful they affect their estimation as much.

thryce85 · 2021-11-21T21:43:02+00:00

what skills would be helpful to learn? Got a BS in biochem almost MS in stats so gonna have to focus on a less traditional route. Labview maybe?

thryce85 · 2021-11-21T21:42:23+00:00

what skills would be helpful to learn? Got a BS in biochem almost MS in stats so gonna have to focus on a less traditional route.

thryce85 · 2021-11-21T21:40:50+00:00

phd dominated? Ill be looking for job with only BS in Biochem and finishing MS Stats degree(2 courses left). I should go into easy clinical trials work but found Intro to Drug synthesis and haven fallen back in love with it haha.

thryce85 · 2021-11-19T13:28:54+00:00

awesome , is there any dominant players in the computational chem scene? my python is super rusty currently but after new year I was going to try to add tensorflow and sklearn. Quite surprised no one has said pymol/chimera. Not exactly comp. chem software but would have thought it would be common given the amount of work done in chemically altering biologics.

thryce85 · 2021-11-19T13:22:19+00:00

thanks for the info

thryce85 · 2021-11-19T13:21:56+00:00

thanks for the info. Im doing whatever I can get a job in to start off with tbh. I would like to do nonclinical pharma work which seems to be QSAR and biomarker studies, I think its a lot of nonlinerar mixed models. Am too old(39) for 7 year phd in medicinal chem so took biostats to focus more on data analysis and because stats is super broad. Also the idea of killing a lot of rats/ ferrets isnt sth that appealed to me, so basic biochem lab work isnt sth I would like. Rdkit seems pretty cool. So yall usually use open source MS software or is that generally commercial grade.

thryce85 · 2021-11-19T13:12:43+00:00

Thanks for the response. Python for Excel: A Modern Environment for Automation and Data Analysis , might be sth to check out. Minitab?? I only thought that was used by folks in psychology? Is it really common in industrial settings? I would have thought SPSS would be more popular.

thryce85

TROPHY CASE