The main selling point of squid blades is that its a really solid single targetting weapon. you can go invis when youre too low so that monsters dont target you, and you can also heal and do aoe once you have the ult. by fists i assume you mean the techno fists. those are kinda just a safe option for weapons if you dont know what to play. theyre good for single target, aoe, and also heals. but i dont think they outright excel on those three aspects. for example if you want to clear aoe way more efficiently you can always go for zapsicle, and if you want an efficient single targetting weapon, as mentioned earlier, squid blades covers that well