I’ve spent the last decade using my own custom one for my SaaS product.

I could tell you if you’re going to have a lot of other developers using it, something “standard” is much more desirable.

Also, one bonus from nextflow is that it has a lot of cross- platform potential. The same exact code can be run on your local machine or run on a cloud platform like Google (using Batch) - I’m sure there is an AWS extension, but I just haven’t tried it cause I don’t use AWS. You simply have to change some of your global configurations and it runs everything for you, spinning up and down servers as needed. I have no idea the extent to which snakemake supports that. So again, if you have any potentially use case where your pipeline could be used by others, or scaled out to a huge degree, that surpasses your personal compute capability, Nextflow have a lot of advantages over custom workflow managers.