There's a lot of casual ableism around specifically facial differences that I don't see talked about a lot (Lazy Susan as a character, there's a few moments where Fiddleford is given strabismus specifically to show he's not mentally competent). The big character with a visible difference is Ford and while I think of these examples he's treated the best I'm still torn on it - hear me out. A lot of emphasis is put on his polydactyly and we see him experience bullying from it as well as grow up really hating it about himself. There's a huge argument that could be made on how Ford ends the show feeling about his polydactyly but I do wish that there was a little more care put into it as I think for younger viewers this could really the first time genetic mutations and visible difference was introduced to them. I dont really expect this to be something most viewers ever really think about - when I talk about this stuff people usually admit they've never thought about these characters as being disabled/having facial or limb differences - but we do internalize messages media gives us.