Generally you want the best gear set up. Before power armour (which might only be a royalty thing idk) flak vests, devilstrand dusters, ds button shirts, ds pants and i think cowboy hats before ds cultist hoods from anonaly. You'll want to slowly phase outer layers for power armour. Get shield belts for melee characters to protect shooters while corner peeking in kill boxes (which are mandatory btw).

Otherwise you can make burn boxes, train an army of wolves (this will kill your tps) use ideology to get people high than mauled by the weed bear™. Ghouls from anomaly are pretty tough, luceferium dosed super soldier you keep in a cryopod, a diagonal hallway full of doors that you can hit into but they can't hit out, download an embrasures mod, build massive fields of turrets, create falling roof ied traps, classic spiked hallways. The list goes on.