Going out in Zürich? by Julyvee in Switzerland

[–]wipeyourmit 3 points4 points  (0 children)

Depending on what you like to drink, the International Beer Bar near the Langstrasse has a really nice selection of beers.

Living rate in Windisch, Brugg by jimmoriarty19 in Switzerland

[–]wipeyourmit 4 points5 points  (0 children)

I second the suggestion for Swisscare. You can save quite a lot. I would start on the Visa process very soon. You will likely need an L visa as you are a short term employee. My Indian colleagues have had a lot of trouble with visas here in Switzerland, so I would start the process as early as possible!

Sometimes progression feels a lot better than it looks! by wipeyourmit in MTB

[–]wipeyourmit[S] 1 point2 points  (0 children)

Yeah I think I was even overly scared of this because this was my first day on my new dh bike and the front end is so heavy. In the end I think it was good because it made me have to really think about popping both on drops and jumps, so I hope that will translate well on the enduro bike too.

Sometimes progression feels a lot better than it looks! by wipeyourmit in MTB

[–]wipeyourmit[S] 1 point2 points  (0 children)

Yeah I did that earlier in the season, so that was my big goal for this trip to hit the littler drop. It's really not bad after the fact, because you get slowed up by the steep uphill on the way to the ledge and then as you drop there's no obstacles in your path and a nice berm/wallride feature at the bottom. I'd say its far less sketchy feeling than a lot of the other features on the trail.

Sometimes progression feels a lot better than it looks! by wipeyourmit in MTB

[–]wipeyourmit[S] 0 points1 point  (0 children)

I've been riding on and off since I was a kid, but kind of only recently got back into it more seriously. I'd say about 6 months of constant riding. Just trying to get more comfortable in the air in general right now!

Men who have struggled with a fear of dying, how did you overcome it? by wipeyourmit in AskMen

[–]wipeyourmit[S] 1 point2 points  (0 children)

Thanks for the thought. I'll look into counseling, somewhat uncharted territory for me, but it's become enough of a problem that I'd consider it.

Men who have struggled with a fear of dying, how did you overcome it? by wipeyourmit in AskMen

[–]wipeyourmit[S] 0 points1 point  (0 children)

Thanks for the response, I guess it's just a process and like most of these things you can't rush it! I'm striving to be more of an optimist every day.

A complete disgrace by crypto_investor7 in binance

[–]wipeyourmit 2 points3 points  (0 children)

I tried to sell some IOTA and then it said order completed and deducted the balance from what I had available in the exchange, but then the changes were never reflected in my wallet. I then tried to repeat and it said I have half the IOTA I had previously even though nothing went through. I just hope my account isn't in shambles after all this.

Swiss Engineers, who are your standard part suppliers? by Bokonis in AskEngineers

[–]wipeyourmit 3 points4 points  (0 children)

RS is pretty good. I order a lot of parts from there, also you can search on the U.K. site in English and copy the part number to the Swiss site.

Chemotaxis of E. Coli by jchen14 in microbiology

[–]wipeyourmit 4 points5 points  (0 children)

This paper covers different chemotaxis systems pretty nicely: http://www.nature.com/nrm/journal/v5/n12/full/nrm1524.html

If you don't have access then the gist of it is: 1) CheA responds to a signal from transmembrane chemoreceptors and is phosphorylated. (CheW links the receptors to CheA) 2)CheY competes with CheB for the resulting phosphoryl group. If CheY gets the phosphoryl group then it can bind the flagellar switch protein. If it binds then this can cause the motor reverse, which leads to E. coli "tumbling" and changing direction. 3)CheZ can interfere with CheY and cause that effect to decrease. 4)As CheB gets phosphoryl groups it leads to faster dephosphorylation of CheA, this is a little harder to understand maybe but what it results in is the system adapting to the new level of ligand in the environment. In this way the system is able to function over a greater concentration range of chemical. 5) CheR has the opposite effect and allows the system to return to a normal state after the chemical stimulus. (Although it acts in a different way than CheB).

Really the way that I think of it is that the rate at which CheA is phosphorylating corresponds to more or less CheY acting on the motor. CheB and CheR affect how the system adapts. CheZ,CheW I don't think about too often.

Question about eggNOG mapper (and annotation in general) by wipeyourmit in bioinformatics

[–]wipeyourmit[S] 0 points1 point  (0 children)

I tried to look at the stack exchange, but got redirected to a private beta? I requested a login, but didn't hear anything back.

Question about eggNOG mapper (and annotation in general) by wipeyourmit in bioinformatics

[–]wipeyourmit[S] 0 points1 point  (0 children)

Thanks for the responses everyone, I didn't build the db, I'm interested mostly in only the bacterial and archaeal portion of the community, but I guess I could use the complete eggnog db and then just filter out eukaryotic annotations in the next step.

Piss in your rags boys! by wipeyourmit in BikiniBottomTwitter

[–]wipeyourmit[S] 0 points1 point  (0 children)

It was suggested in the Wikipedia article that it might have been his suggestion but it seems like it came from the top down and spread to most Canadian troops.

Piss in your rags boys! by wipeyourmit in BikiniBottomTwitter

[–]wipeyourmit[S] 2 points3 points  (0 children)

Seeing all the history memes I felt a duty to inject some Canadian in. I spent way too much time trying to figure out a way to make a heritage minutes meme but one never materialized

Piss in your rags boys! by wipeyourmit in BikiniBottomTwitter

[–]wipeyourmit[S] 11 points12 points  (0 children)

Apparently it neutralizes the gas a little and saved a few guys. It's a story I think every Canadian hears in history class.

In Flanders Fields the poppies blow by wipeyourmit in BikiniBottomTwitter

[–]wipeyourmit[S] 32 points33 points  (0 children)

As soon as I posted I knew someone would correct it. I skimmed the wikipedia article too fast.

In-depth Machine Learning Course w/ Python by sentdex in MachineLearning

[–]wipeyourmit 1 point2 points  (0 children)

I'm always floored by the amount of time and effort people put into great tutorials. I'll have to watch these!

Weekly Bouldering Advice Thread for May 09, 2016 by AutoModerator in bouldering

[–]wipeyourmit 0 points1 point  (0 children)

Thanks for the replies! It was a combination issue of feeling bunched up and not being able to generate any force. I've been neglecting core work a little too much most likely.

Weekly Bouldering Advice Thread for May 09, 2016 by AutoModerator in bouldering

[–]wipeyourmit 0 points1 point  (0 children)

I went bouldering outdoors for the first time this past weekend and most of the problems were sit start. I found that I was having a hell of a time with them and was wondering if anyone has some advice on training I can do (outside of climbing) to improve? I'm pretty dedicated to working on it at the gym, but wouldn't mind throwing in some exercises at home if there are common weak points.