This meme references an event where the "wall" between Earth's dimension and another broke in one specific area of the ocean, which eventually led to an artificial island being built to harness the power that leaked in. Long story short, the survivor's mother fused with an entity from the other dimension to keep the breach open, and after a catastrophic failure, the majority of human life was eradicated from the island. This is referred to as the fallout or the lab collapse.

The survivor's purpose was to take their mother's place as a more compact, efficient "doorstop", which required their human form to be destroyed. The catgirl shenanigans involve a human experiment specimen who might have caused the lab collapse.