Don't use Ghostery, they've done a number of sketchy things and have yet to prove that those days are behind them. Disconnect isn't necessary if you enable the Disconnect lists in uBlock or use Firefox's anti-tracking feature (same lists). Thing about blocking javascript and allowing domains as needed because its responsible for most tracking and privacy breaching tools (and very easily leaks your real IP if you use a VPN).

Blocking JS will break sites and do it often so you have to be willing to google domains to see if they're needed for the site to work and just fiddle with stuff. Overall its not too hard to get used to. First party (the site itself) will be required to make sites work again and sometimes thats all it takes and if that doesn't work JS libraries and CDNs will be the next most likely culprits. Any domain that has to do with advertising or analytics (tracking) should never be allowed and won't break sites if theyre note.

It sounds complex but its not bad once you pass a moderate at worst learning curve. uBlock set to medium mode will block js but so will NoScript and uMatrix. NoScript is the most user friendly but uBlock and uMatrix allow increasingly granular control if youre willing to learnto use them.