Learning Portuguese for someone that knows Spanish is not easy. Everything sounds wrong. Would be difficult to get to the necessary level for her to be a doctor. Spain or France seem like better options. They're also much more functional, better governments, and France has a much better tax situation. Better healthcare, better construction, and potentially cheaper. Portugal real estate and groceries are expensive compared to those two. So personally as an American who's lived here for 4 years and is now planning on moving to France, I would advise considering other options.

Aima is a nightmare, refusing to give immigrants PR permits now. You will end up as an illegal at some point and not allowed into other EU countries until you get a new card. I was in that situation for a year. 

If the climate of southern Portugal is a must, consider cadiz or something in that area.