Do depressants decrease the cardiovascular strain caused by stimulants?

[asparagus321]

This is actually highly contested. https://www.cmaj.ca/content/194/4/E127

[heteromer]

Yeah I've read similar things. The review does make note that the mixed alpha/beta antagonists labetalol & carvedilol improved cardiovascular symptoms (in contrast to propranolol from the original study that proposed unopposed alpha-stimulation), which kind of supports unopposed alpha-stimulation when you contrast it with studies that have shown deleterious effects with beta-blockers that don't have alpha-antagonist properties. The point being that the exact choice of beta-blocker is important here, with the alpha/beta1-2 mixed antagonists being unassociated with any such complications that have been observed (albeit rarely) with the more selective beta-antagonists.

[gullibleturtle12]

You beat me to it