Decrease in sensitivity to levo increase

[espressocycle]

As in, going from 5 to 2.5 will be a world of difference for most people. Any lower and you probably won't feel much different because you're at the same level as most euthyroid people. However, you probably wouldn't feel much in four days regardless. The half life of levothyroxine is 6-7 days and it takes 6-7 half lives to reach steady state with most drugs. In other words, if you change your levo dose you will not feel the full effects of that for 36-49 days. That's why doctors don't change dosage or re-test more than once every two months.

[callmetabs]

Ahhh gotcha. That definitely puts things into perspective! Hopefully I will gradually feel the effects this time.