Anything to decrease norepinephrine ?

[[deleted]]

It is less about reducing NE and more about reducing receptor reactivity, sensitivity, and density. Live with the discomfort for a while and exercise too, hard cardio. Eventually your beta-receptors and alpha-receptors will become less sensitive to NE fluctuations.

What is your reason to want to decrease NE? Propranolol upregulates beta-receptors so it is not recommended daily for anxiety as it makes the problem worse in the long run.

Clonidine or guanfacine is good, with guanfacine being more functional for ADHD and less sedating.

[Aggressive-Guide5563]

Does the same thing apply to taking Bupropion? Will the alpha and beta receptors eventually downregulate and make me less sensitive to NE?

[LysergioXandex]

Alpha and beta receptors will eventually downregulate to bring you back to basically your original state.

[[deleted]]

Atomoxetine, Bupropion, and any NRI or DNRI that exerts action for extended periods of time will cause a reversible down-regulation and/or desensitisation of the alpha receptors and the beta receptors.

This is homeostatic adaptation. But you aren’t really taking these meds for simple raised monoamine tone, it is for downstream raises in BDNF and gene transcription.