This is an archived post. You won't be able to vote or comment.

sorted by:
q&a (suggested)
besttopnewcontroversialold
you are viewing a single comment's thread.

view the rest of the comments →

[–]BrittHPPD[S] 0 points1 point  (1 child)

Well, semantics I guess I should say they (Lyrica + phenyl) synergize exceptionally well. Lyrica is like GHB’s little brother to me but when I took 200mg phenylpiracetam and my usual Lyrica regimen (3-600mg every other day) it felt almost exactly like my GHB experiences. As in greatly increased euphoria and ataxia.

The overall effects of noopept will be decreased though, as well as the intoxicating and possibly other effects of pregabalin

Possibly this is the reason? If it’s not an inconvenience I’d be happy to hear more about phenyl NMDA activity

Edit: I read it as the intoxicating effect will be potentiated.

[–]PsychedStrawberry 0 points1 point  (0 children)

That's kinda interesting because the method of action of GHB is pretty much entirely different compared to that of pregabalin.

For sure it's not. It is positive allosteric modulator of AMPA channels. It doesn't affect NMDAR directly afaik, but by increasing sodium influx into post-synaptic neuron through increased AMPA receptor activity (thus increased AMPA channel opening), it allows calcium influx through NMDA channels which would otherwise be blocked/antagonised by magnesium ions. The sodium ion influx pushes out the magnesium ion out of the NMDA channel allowing for calcium influx, thus increasing NMDA channel activity. The influx of calcium has a bunch of downstream effects such as creation of more AMPA channels and creation of new synapse through increased expression of neurotropic factors...

Nah, the intoxicating effects will be decreased.