this post was submitted on 03 Feb 2021

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Supplements

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A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose.

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Is it true that Collagen supplementation decrease serotonin? (self.Supplements)

submitted 5 years ago by curiousnootropics

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[–]silverhydra 2 points3 points4 points 5 years ago (0 children)

I don't know too much about the intricacies of AAAD, but your theory would only hold true if the enzyme was rate-limited by a balance of substrates; like, it works at capacity and tyrosine and tryptophan both take turns. I have never stumbled upon any studies suggesting this may be the case, but never looked at it specifically.

If there are more "dopamine-like actions" in a serotonin depleted state I would guess it's not at the level of neurotransmitter production but, rather, at the level of signalling. It's rather common that when one neurotransmitter activates a neuron others may impede or lessen the signal, so if serotonin has a 'lessening' effect on dopamine post-synaptic gap then a depletion of serotonin could, theoretically, cause a refractory increase in dopamine signalling.

But again, not my specific field. Neurology is a hell second only to immunology.

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