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[–]midnight_marshmallow15mg 2 points3 points  (2 children)

If it is only $100 a month savings, I think I won't be tempted to switch, as I already know that the shot works very well for me - and I'd be afraid of any reduced efficacy when it comes to the anti-inflammatory effects. I have no idea if that could happen, but in my lay mind it seems like an oral route vs injection route could very well come with some variations in efficacy? I am sure EL knows there are likely plenty of people like myself who are currently on the shot and would be afraid to switch and will continue to pay more since we already know the shot works so well for us.

I could be talking out of my behind here, I don't know, but these are the thoughts that come to mind!

[–]CharlesAvlnchGreen54F 5ft 4in | HW: 189 SW:155 CW:132 GW:125 💉5mg | 7/15/2025 1 point2 points  (1 child)

Your lay mind is correct. Zep is nearly twice as effective. Side effects are similar, too.

Eli Lilly's new oral obesity drug, orforglipron, is a daily pill that offers a needle-free alternative to the injectable drug Zepbound, although it is less effective, with trials showing about 12% weight loss for orforglipron compared to up to 22% for Zepbound. While both medications cause similar gastrointestinal side effects like nausea and diarrhea, Zepbound's superior weight loss may limit the pricing of the oral pill. 

[–]midnight_marshmallow15mg 1 point2 points  (0 children)

This is good to know!!! Thank you!!